Pearlman D L, Youngberg B, Engelhard C
J Am Acad Dermatol. 1986 Dec;15(6):1247-52. doi: 10.1016/s0190-9622(86)70298-3.
We report use of a new weekly pulse dosing schedule of 5% fluorouracil under occlusion for topical treatment of recalcitrant psoriasis. This schedule eliminates the severe local toxicity reported in continuous dosing schedules. The thirteen outpatients completing this study were given continuous topical application of fluorouracil for a mean of 2 to 3 days per week; mean duration of therapy was 15.7 weeks. Eleven patients had an average of 90% clearing of actively treated lesions; 6% clearing was obtained with placebo. At 3-month follow-up examination, improvement was maintained in five patients, was maintained by at least 50% in two, and was lost in four. The five patients with remission at 3 months reported continued remission for up to an additional 8 months. This pulse dosing schedule makes topical fluorouracil under occlusion a useful, safe treatment for limited plaque psoriasis that does not respond to topical corticosteroid therapy.
我们报告了一种新的每周脉冲给药方案，即采用5%氟尿嘧啶封包局部治疗顽固性银屑病。该方案消除了连续给药方案中报道的严重局部毒性。完成本研究的13名门诊患者接受氟尿嘧啶局部连续给药，平均每周2至3天；平均治疗持续时间为15.7周。11名患者接受积极治疗的皮损平均清除率达90%；安慰剂组清除率为6%。在3个月的随访检查中，5名患者病情持续改善，2名患者改善至少维持50%，4名患者病情复发。5名在3个月时病情缓解的患者报告病情持续缓解长达8个月。这种脉冲给药方案使封包下的局部氟尿嘧啶成为治疗对局部皮质类固醇治疗无反应的局限性斑块状银屑病的一种有效、安全的治疗方法。
