洋地黄的治疗作用与毒性作用：威廉·威瑟林，1785年。
Therapeutic and toxic effects of digitalis: William Withering, 1785.
作者信息
Bessen H A
出版信息
J Emerg Med. 1986;4(3):243-8. doi: 10.1016/0736-4679(86)90048-x.
PMID:3543113
Abstract
William Withering's classic description of the effects of digitalis was published in 1785. Although he was largely unaware of the drug's cardiac effects, he successfully treated many patients with congestive heart failure. He also recorded many striking examples of digitalis toxicity. This review highlights Withering's experience with "the foxglove," and summarizes modern concepts of digitalis efficacy and toxicity.
摘要
威廉·威瑟林关于洋地黄作用的经典描述发表于1785年。尽管他基本上没有意识到该药物对心脏的作用，但他成功地治疗了许多充血性心力衰竭患者。他还记录了许多洋地黄毒性的显著案例。这篇综述重点介绍了威瑟林使用“毛地黄”的经验，并总结了现代关于洋地黄疗效和毒性的概念。
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