教老狗新把戏：重新定位天然产物及其衍生物的药物发现。
Teaching an old dog new tricks: Drug discovery by repositioning natural products and their derivatives.
机构信息
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E. Leigh Street, Richmond, VA 23298, USA.
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 E. Leigh Street, Richmond, VA 23298, USA.
出版信息
Drug Discov Today. 2022 Jul;27(7):1936-1944. doi: 10.1016/j.drudis.2022.02.007. Epub 2022 Feb 16.
Abstract
Given the substantial cost and low success rate of drug discovery and development, repositioning existing drugs to treat new diseases has gained significant attention in recent years, with potentially lower development costs and shorter time frames. Natural products show great promise in drug repositioning because they have been used for various medical purposes for thousands of years. In this review, we discuss the drug repositioning of six prototypical natural products and their derivatives to reveal new drug-disease associations. We also highlight opportunities and challenges in natural product-based drug repositioning for future reference.
摘要
鉴于药物发现和开发的成本高昂且成功率低，近年来，将现有药物重新用于治疗新疾病引起了广泛关注，因为这种方法可能具有更低的开发成本和更短的时间框架。天然产物在药物重新定位方面显示出巨大的潜力，因为它们已经被用于各种医疗用途数千年。在这篇综述中，我们讨论了六种典型天然产物及其衍生物的药物重新定位，以揭示新的药物-疾病关联。我们还强调了基于天然产物的药物重新定位的机遇和挑战，以供未来参考。
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