Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy , Jordan University of Science and Technology , Irbid 22110 , Jordan.
Department of Chemistry and Biochemistry , University of North Carolina at Greensboro , Greensboro , North Carolina 27402 , United States.
Org Lett. 2019 Jan 18;21(2):529-534. doi: 10.1021/acs.orglett.8b03769. Epub 2019 Jan 8.
Six fungal metabolites, of which five were new, including one (1) with a dioxa[4.3.3]propellane ring system, were discovered, identified, and structurally elucidated from Neosetophoma sp. (strain MSX50044); these compounds are similar to the bis-tropolone, eupenifeldin. Three of the meroterpenoids are potent cytotoxic agents against breast, ovarian, mesothelioma, and lung cancer cells with nanomolar IC values while not inducing mitochondrial toxicity at 12.5 μM.
从 Neosetophoma sp.（菌株 MSX50044）中发现、鉴定并结构阐明了 6 种真菌代谢产物，其中 5 种为新化合物，包括具有二氧杂[4.3.3]丙烷环系统的 1 种化合物；这些化合物与双曲松、依普黄酮类似。其中 3 种混合萜类化合物对乳腺癌、卵巢癌、间皮瘤和肺癌细胞具有很强的细胞毒性，IC 值为纳摩尔级，而在 12.5 μM 时不会诱导线粒体毒性。
