Zhang Chunmei, Liu Ning
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Pharmacol. 2022 Mar 30;13:855488. doi: 10.3389/fphar.2022.855488. eCollection 2022.
Energy metabolism reprogramming is the characteristic feature of tumors. The tumorigenesis, metastasis, and drug resistance of ovarian cancer (OC) is dependent on energy metabolism. Even under adequate oxygen conditions, OC cells tend to convert glucose to lactate, and glycolysis can rapidly produce ATP to meet their metabolic energy needs. Non-coding RNAs (ncRNAs) interact directly with DNA, RNA, and proteins to function as an essential regulatory in gene expression and tumor pathology. Studies have shown that ncRNAs regulate the process of glycolysis by interacting with the predominant glycolysis enzyme and cellular signaling pathway, participating in tumorigenesis and progression. This review summarizes the mechanism of ncRNAs regulation in glycolysis in OC and investigates potential therapeutic targets.
能量代谢重编程是肿瘤的特征性表现。卵巢癌（OC）的肿瘤发生、转移和耐药性均依赖于能量代谢。即使在氧气充足的条件下，OC细胞也倾向于将葡萄糖转化为乳酸，糖酵解可快速产生ATP以满足其代谢能量需求。非编码RNA（ncRNAs）直接与DNA、RNA和蛋白质相互作用，在基因表达和肿瘤病理学中发挥重要的调控作用。研究表明，ncRNAs通过与主要的糖酵解酶和细胞信号通路相互作用来调节糖酵解过程，参与肿瘤的发生和发展。本文综述了ncRNAs在OC糖酵解中的调控机制，并探讨了潜在的治疗靶点。
