Abbas Beenish, Abbas Sana, Malik Saadia Muneer, Rahim Majida, Umair Muhammad, Khurshid Zohaib
Department of Pedodontics, Foundation University College of Dentistry, Islamabad, Pakistan.
Department of Anesthesiology, National University of Medical Science, Islamabad, Pakistan.
Int J Dent. 2022 Apr 6;2022:9750460. doi: 10.1155/2022/9750460. eCollection 2022.
To determine the correlation between consanguineous marriages and dental anomalies. . A cross-sectional analytical study.
This cross-sectional analytical multicentered study was carried out at Foundation University College of Dentistry after approval of the Ethical Research Committee (ERC) from September 2021 to November 2021 in Pakistan. All pediatric patients (4-10 years old) with dental malformations undergoing dental procedures or examinations and born with spontaneous vaginal delivery and uncomplicated cesarean section participated in the study. First, second, and third-degree relatives' marriages of parents were used to define consanguinity. The Basic Pay Scale was the reference of estimation of socioeconomic status. Participants with a history of orofacial trauma, pertinent parental history (infertility, hormonal treatment, or infectious diseases during pregnancy, conception with assisted reproductive techniques, prolonged complicated labor, premature deliveries, and twin births), and prolonged hospital admission immediately after birth were excluded from the study.
The mean maternal and paternal age was recorded to be 23.86 ± 5.4 and 27.07 ± 9.6, respectively, whereas the mean age of participants was 6.60 ± 1.67. There were 297 children with congenital abnormalities, with 203 (68.4%) males and 94 (31.6%) females. The prevalence of consanguineous marriage was found to be in 210 (70.7%) participants. Congenital dental anomalies correlation was found to be significant with consanguineous marriages ( value <0.001). Consanguineous marriages were more frequent in the lower socioeconomic group when compared with the middle and upper socioeconomic groups, respectively (74.7% vs. 8.1% vs. 17.2%, value 0.007).
Congenital dental anomalies were significantly prevalent in consanguineous marriages with greater incidence in lower socioeconomic groups. Consanguineous marriages have the propensity to transmute population conformation, but due to religious and social beliefs, literature is hesitant to ascribe congenital dental anomalies persuasive relevance with consanguinity.
确定近亲婚姻与牙齿异常之间的相关性。横断面分析研究。
这项多中心横断面分析研究于2021年9月至2021年11月在巴基斯坦基础大学牙科学院开展，经伦理研究委员会（ERC）批准。所有患有牙齿畸形、正在接受牙科治疗或检查、自然阴道分娩且剖宫产无并发症的儿科患者（4至10岁）参与了该研究。父母的一级、二级和三级亲属婚姻用于定义近亲关系。基本工资等级是社会经济地位评估的参考标准。有口面部创伤史、相关父母病史（不孕、孕期激素治疗或传染病、辅助生殖技术受孕、长时间复杂分娩、早产和双胎分娩）以及出生后立即长期住院的参与者被排除在研究之外。
记录的母亲和父亲平均年龄分别为23.86±5.4岁和27.07±9.6岁，而参与者的平均年龄为6.60±1.67岁。有297名患有先天性异常的儿童，其中203名（68.4%）为男性，94名（31.6%）为女性。发现近亲婚姻的患病率在210名（70.7%）参与者中。发现先天性牙齿异常与近亲婚姻存在显著相关性（ 值<0.001）。与社会经济中上层群体相比，近亲婚姻在社会经济下层群体中更为常见（分别为74.7%对8.1%对17.2%， 值0.007）。
先天性牙齿异常在近亲婚姻中显著普遍，在社会经济较低群体中发病率更高。近亲婚姻有改变人口结构的倾向，但由于宗教和社会信仰，文献对于将先天性牙齿异常与近亲关系认定为有说服力的关联犹豫不决。
