McNicol A M
J Pathol. 1986 Nov;150(3):169-73. doi: 10.1002/path.1711500304.
The immunohistochemical demonstration of neurofilament (NF) polypeptide was used to identify nerves in a series of 17 pituitary adenomas. NF-positive fibres were present in two out of five corticotroph adenomas sited deep in the anterior lobe, in one out of five sited in the intermediate zone and in two out of seven non-corticotroph adenomas. Such nerve fibres were often seen in relation to blood vessels. The distribution of alpha-MSH immunoreactive cells was examined in 25 normal pituitaries and in 23 cases of Cushing's disease. Such cells were scattered throughout the normal gland and there was no increase in numbers in pregnancy. alpha-MSH was demonstrated in 18 corticotroph adenomas in Cushing's disease. There was no correlation with the site of the tumour or the presence of nerve fibres. alpha-MSH cells were distributed normally in the para-adenomatous gland. Crooke's hyaline change and alpha-MSH coexisted in some corticotrophs. These findings support the concept that 'intermediate lobe' function, as found in animals, has no discrete anatomical location in man.
运用免疫组织化学方法显示神经丝（NF）多肽，以鉴定一系列17例垂体腺瘤中的神经。在前叶深部的5例促肾上腺皮质激素细胞腺瘤中，有2例存在NF阳性纤维；在中间带的5例中，有1例存在；在7例非促肾上腺皮质激素细胞腺瘤中，有2例存在。此类神经纤维常可见于血管周围。在25例正常垂体和23例库欣病病例中检查了α-促黑素（α-MSH）免疫反应性细胞的分布。此类细胞散布于整个正常腺体，孕期数量无增加。在库欣病的18例促肾上腺皮质激素细胞腺瘤中显示有α-MSH。其与肿瘤部位或神经纤维的存在无相关性。α-MSH细胞在腺瘤旁腺体中分布正常。在一些促肾上腺皮质激素细胞中，克鲁克透明变性与α-MSH共存。这些发现支持这样一种观点，即动物中所见的“中间叶”功能在人类中并无独立的解剖学位置。
