Fehn M, Farquharson M A, Sautner D, Saeger W, Lüdecke D K, McNicol A M
Department of Pathology, Marienkrankenhaus, Hamburg, Germany.
J Pathol. 1993 Mar;169(3):335-9. doi: 10.1002/path.1711690310.
Pro-opiomelanocortin (POMC) mRNA was demonstrated in pituitary adenomas from 16 patients with Cushing's disease and 10 with Nelson's syndrome. The intensity of signal was significantly greater in Nelson's syndrome than in Cushing's disease and there was a trend towards a greater proportion of positive cells. This probably reflects inhibition of POMC gene expression by the high circulating levels of cortisol in Cushing's disease. In the para-adenomatous gland, the intensity of signal was variable in cells showing Crooke's hyaline change, ranging from negative to strongly positive, in keeping with the functional heterogeneity of corticotrophs. In one case, junctional corticotrophs were present and these were more intensely stained than anterior lobe corticotrophs in the same gland. This supports the concept that these cells are subject to different regulatory influences from corticotrophs in the anterior lobe. Whether this is related to differences in embryological origins or to local factors is at present unclear.
在16例库欣病患者和10例纳尔逊综合征患者的垂体腺瘤中检测到阿片促黑激素皮质素原（POMC）mRNA。纳尔逊综合征中的信号强度显著高于库欣病，并且阳性细胞比例有更高的趋势。这可能反映出库欣病中高循环水平的皮质醇对POMC基因表达的抑制作用。在腺瘤旁腺中，显示克鲁克透明变性的细胞信号强度各不相同，从阴性到强阳性，这与促肾上腺皮质激素细胞的功能异质性一致。在1例病例中，存在连接部促肾上腺皮质激素细胞，这些细胞比同一腺体中的前叶促肾上腺皮质激素细胞染色更深。这支持了这样一种概念，即这些细胞受到与前叶促肾上腺皮质激素细胞不同的调节影响。目前尚不清楚这是否与胚胎起源差异或局部因素有关。
