Song Hongdong, Wang Qingyu, He Aijing, Li Sen, Guan Xiao, Hu Yawen, Feng Siyi
School of Health Science and Engineering, National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center, University of Shanghai for Science and Technology, Shanghai 200093, China.
School of Health Science and Engineering, National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center, University of Shanghai for Science and Technology, Shanghai 200093, China.
Food Chem. 2022 Sep 15;388:132903. doi: 10.1016/j.foodchem.2022.132903. Epub 2022 Apr 6.
Hordein nanoparticles have been successfully fabricated to encapsulate EGCG. The present study aimed to investigate the effect of hordein nanoparticles encapsulation on antioxidant activity, storage stability and in vitro release of EGCG. The antioxidant activities of EGCG before and after encapsulation by hordein nanoparticles had no significant difference. The 28-day storage experiments indicated that EGCG-hordein nanoparticles had a good storage stability in terms of average diameter and zeta potential. Meanwhile, the stability of EGCG was significantly improved by hordein nanoparticles encapsulation. The remaining amount of encapsulated EGCG was 1.31-fold and 1.52-fold higher than that of free EGCG at 4 °C and 25 °C, respectively. The release study in the simulated gastric or intestinal fluids suggested that hordein nanoparticles could slow down the release of EGCG in the simulated gastric or intestinal fluids. These results showed that encapsulation of EGCG using hordein nanoparticles could be a promising approach to improve its stability.
已成功制备出用于包封表没食子儿茶素没食子酸酯（EGCG）的大麦醇溶蛋白纳米颗粒。本研究旨在探究大麦醇溶蛋白纳米颗粒包封对EGCG抗氧化活性、储存稳定性及体外释放的影响。大麦醇溶蛋白纳米颗粒包封前后EGCG的抗氧化活性无显著差异。28天的储存实验表明，就平均直径和ζ电位而言，EGCG-大麦醇溶蛋白纳米颗粒具有良好的储存稳定性。同时，大麦醇溶蛋白纳米颗粒包封显著提高了EGCG的稳定性。在4℃和25℃下，包封的EGCG剩余量分别比游离EGCG高1.31倍和1.52倍。在模拟胃液或肠液中的释放研究表明，大麦醇溶蛋白纳米颗粒可减缓EGCG在模拟胃液或肠液中的释放。这些结果表明，用大麦醇溶蛋白纳米颗粒包封EGCG可能是提高其稳定性的一种有前景的方法。
