Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States.
University Hospitals Seidman Cancer Center, Cleveland, OH 44106, United States.
Oral Oncol. 2022 May;128:105861. doi: 10.1016/j.oraloncology.2022.105861. Epub 2022 Apr 15.
To identify predictors of overall survival (OS) in oropharyngeal squamous cell carcinoma (OPSCC) patients who achieved complete response (CR).
We performed a retrospective study of OPSCC patients who achieved CR from a single academic medical center. Associations between OS, AJCC 8th edition staging system, definitive treatment choice, smoking history, and p16 status were assessed.
p16+ status was associated with favorable prognosis for CR (p < 0.001) but not non-CR (p = 0.67) patients. For early stage, p16+ OPSCC patients who achieved CR, surgery + adjuvant radiation (RT) treatment was more durable compared to concurrent chemoradiation (CRT), particularly in smokers.
Curative intent treatment choice and smoking history has an impact on the long-term OS of the CR p16+ OPSCC cohort. Prospective studies to define the optimal multi-modality treatment option to manage p16+ OPSCC patients is needed.
确定达到完全缓解（CR）的口咽鳞状细胞癌（OPSCC）患者的总生存（OS）的预测因素。
我们对单家学术医疗中心的达到 CR 的 OPSCC 患者进行了回顾性研究。评估了 OS、第 8 版 AJCC 分期系统、明确治疗选择、吸烟史和 p16 状态之间的关联。
p16+状态与 CR 患者的良好预后相关（p<0.001），但与非 CR 患者无关（p=0.67）。对于达到 CR 的早期 p16+OPSCC 患者，手术+辅助放疗（RT）治疗比同期放化疗（CRT）更持久，尤其是在吸烟者中。
有治愈意图的治疗选择和吸烟史对 CR p16+OPSCC 队列的长期 OS 有影响。需要前瞻性研究来确定管理 p16+OPSCC 患者的最佳多模式治疗选择。
