In Vitro/In Vivo Translation-Complex In Vitro Models, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.
CN Bio Innovations Ltd, Cambridge, U.K.
Biochem Soc Trans. 2022 Apr 29;50(2):665-673. doi: 10.1042/BST20200661.
As an emerging hot topic of the last decade, Organ on Chip (OoC) is a new technology that is attracting interest from both basic and translational scientists. The Biochemical Society, with its mission of supporting the advancement of science, with addressing grand challenges that have societal impact, has included OoC into their agenda to review the current state of the art, bottlenecks and future directions. This conference brought together representatives of the main stakeholders in the OoC field including academics, end-users, regulators and technology developers to discuss and identify requirements for this new technology to deliver on par with the expectations and the key challenges and gaps that still need to be addressed to achieve robust human-relevant tools, able to positively impact decision making in the pharmaceutical industry and reduce overreliance on poorly predictive animal models.
作为过去十年的新兴热门话题，器官芯片（Organ on Chip，OoC）是一项吸引基础和转化科学家关注的新技术。生物化学学会的使命是支持科学的进步，解决具有社会影响的重大挑战，已将 OoC 纳入其议程，以审查该技术的最新现状、瓶颈和未来方向。本次会议汇集了 OoC 领域的主要利益相关者代表，包括学术界、终端用户、监管机构和技术开发商，共同讨论和确定这项新技术的要求，以达到预期水平，并解决关键挑战和差距，从而实现稳健的、与人类相关的工具，能够积极影响制药行业的决策，并减少对预测效果不佳的动物模型的过度依赖。
