Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.
Organogenesis. 2023 Dec 31;19(1):2278236. doi: 10.1080/15476278.2023.2278236. Epub 2023 Nov 15.
In drug development, conventional preclinical and clinical testing stages rely on cell cultures and animal experiments, but these methods may fall short of fully representing human biology. To overcome this limitation, the emergence of organ-on-a-chip (OOC) technology has sparked interest as a transformative approach in drug testing research. By closely replicating human organ responses to external signals, OOC devices hold immense potential in revolutionizing drug efficacy and safety predictions. This review focuses on the advancements, applications, and prospects of OOC devices in drug testing. Based on the latest advances in the field of OOC systems and their clinical applications, this review reflects the effectiveness of OOC devices in replacing human volunteers in certain clinical studies. This review underscores the critical role of OOC technology in transforming drug testing methodologies.
在药物开发中，传统的临床前和临床测试阶段依赖于细胞培养和动物实验，但这些方法可能无法完全代表人体生物学。为了克服这一局限性，器官芯片（OOC）技术的出现引起了人们的兴趣，被视为药物测试研究中的一种变革性方法。OOC 设备通过紧密复制人体器官对外界信号的反应，在革新药物疗效和安全性预测方面具有巨大的潜力。本综述重点介绍了 OOC 设备在药物测试中的进展、应用和前景。基于 OOC 系统领域的最新进展及其临床应用，本综述反映了 OOC 设备在某些临床研究中替代人类志愿者的有效性。本综述强调了 OOC 技术在改变药物测试方法学方面的关键作用。
