co-infection in patients with COVID-19.

To assess the impact of infection on the course of COVID-19. The authors included 809 patients with COVID-19 in this retrospective study: 55 had infection, 23 had -negative antibiotic-associated diarrhea and 731 had no diarrhea. in feces was determined by immunochromatographic test for its toxins. infection was associated with increased risk of death (hazard ratio = 2.6; p = 0.021), especially after 20 days of disease (hazard ratio = 6.5; p < 0.001). infection-associated diarrhea was longer and more severe than -negative antibiotic-associated diarrhea. Unlike patients with -negative antibiotic-associated diarrhea, patients with infection were admitted to the intensive care unit and needed mechanical ventilation more often than those without diarrhea. infection worsens the course and prognosis of COVID-19.