Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, 8-2 Trubetskaya str., Moscow, 119991, Russian Federation.
The Interregional Public Organization 'Scientific Community for the Promotion of the Clinical Study of the Human Microbiome', Pogodinskaya Street, 1, Building 1, Moscow, 119435, Russian Federation.
Future Microbiol. 2022 Jun;17:653-663. doi: 10.2217/fmb-2021-0145. Epub 2022 Apr 20.
To assess the impact of infection on the course of COVID-19. The authors included 809 patients with COVID-19 in this retrospective study: 55 had infection, 23 had -negative antibiotic-associated diarrhea and 731 had no diarrhea. in feces was determined by immunochromatographic test for its toxins. infection was associated with increased risk of death (hazard ratio = 2.6; p = 0.021), especially after 20 days of disease (hazard ratio = 6.5; p < 0.001). infection-associated diarrhea was longer and more severe than -negative antibiotic-associated diarrhea. Unlike patients with -negative antibiotic-associated diarrhea, patients with infection were admitted to the intensive care unit and needed mechanical ventilation more often than those without diarrhea. infection worsens the course and prognosis of COVID-19.
为评估 感染对 COVID-19 病程的影响。作者在这项回顾性研究中纳入了 809 例 COVID-19 患者：55 例有 感染，23 例有 -阴性抗生素相关性腹泻，731 例无腹泻。粪便中的 通过免疫层析试验检测其毒素来确定。感染与死亡风险增加相关（危险比=2.6；p=0.021），尤其是在疾病发生 20 天后（危险比=6.5；p<0.001）。与 -阴性抗生素相关性腹泻相比， 感染相关腹泻持续时间更长，更严重。与 -阴性抗生素相关性腹泻患者不同， 感染患者更常被收入重症监护病房并需要机械通气。 感染可使 COVID-19 的病程和预后恶化。
