• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

鞘内注射布比卡因后癫痫持续状态:病例报告。

Status Epilepticus Following Intrathecal Administration of Bupivacaine: A Case Report.

机构信息

Intensive Care Medicine AZ Delta, Roeselare, Belgium.

出版信息

J Investig Med High Impact Case Rep. 2022 Jan-Dec;10:23247096221090841. doi: 10.1177/23247096221090841.

DOI:10.1177/23247096221090841
PMID:35440218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9024154/
Abstract

Spinal anesthesia is common practice and rarely causes complications. Although extended experience is present, seldom side effects of this technique and the administration of intrathecal local anesthetics and/or opioids can occur. We present a case in which a 76-year old woman undergoing total hip arthroplasty received a low dose of intrathecal bupivacaine and sufentanil. One hour after administration, she developed myoclonic seizures of the lower extremities followed by generalized tonic-clonic seizures and status epilepticus. We conclude that status epilepticus is a rare and possible lethal side effect of intrathecal bupivacaine. Symptoms may be misleading, highlighting the importance of early recognition and adequate management.

摘要

脊髓麻醉是一种常见的做法,很少引起并发症。尽管有丰富的经验,但这种技术和鞘内局部麻醉剂和/或阿片类药物的给药偶尔会出现副作用。我们报告了一例 76 岁女性患者在接受全髋关节置换术时接受了低剂量的布比卡因和舒芬太尼。给药后 1 小时,她出现下肢肌阵挛性抽搐,随后出现全身强直阵挛性发作和癫痫持续状态。我们得出结论,癫痫持续状态是鞘内布比卡因罕见且可能致命的副作用。症状可能具有误导性,强调了早期识别和充分管理的重要性。

相似文献

1
Status Epilepticus Following Intrathecal Administration of Bupivacaine: A Case Report.鞘内注射布比卡因后癫痫持续状态:病例报告。
J Investig Med High Impact Case Rep. 2022 Jan-Dec;10:23247096221090841. doi: 10.1177/23247096221090841.
2
Intrathecal bupivacaine and morphine toxicity leading to transient hypotension and delayed status epilepticus.鞘内布比卡因和吗啡中毒导致短暂低血压和迟发性癫痫持续状态。
Am J Emerg Med. 2020 May;38(5):1046.e5-1046.e7. doi: 10.1016/j.ajem.2019.12.055. Epub 2020 Jan 8.
3
Super-refractory status epilepticus, rhabdomyolysis, central hyperthermia and cardiomyopathy attributable to spinal anesthesia: a case report and review of literature.超难治性癫痫持续状态、横纹肌溶解症、中枢性高热和脊髓麻醉相关性心肌病:病例报告及文献复习。
BMC Anesthesiol. 2024 Apr 6;24(1):132. doi: 10.1186/s12871-024-02485-x.
4
Intrathecal magnesium sulfate does not reduce the ED of intrathecal hyperbaric bupivacaine for cesarean delivery in healthy parturients: a prospective, double blinded, randomized dose-response trial using the sequential allocation method.鞘内注射硫酸镁不能降低健康产妇剖宫产时鞘内注射高比重布比卡因的有效剂量:一项采用序贯分配法的前瞻性、双盲、随机剂量反应试验。
BMC Anesthesiol. 2017 Jan 17;17(1):8. doi: 10.1186/s12871-017-0300-z.
5
ED 50 and ED 95 of intrathecal bupivacaine coadministered with sufentanil for cesarean delivery under combined spinal-epidural in severely preeclamptic patients.在严重子痫前期患者中,鞘内注射布比卡因与舒芬太尼联合用于腰麻-硬膜外联合麻醉下剖宫产的半数有效剂量(ED50)和95%有效剂量(ED95) 。
Chin Med J (Engl). 2015 Feb 5;128(3):285-90. doi: 10.4103/0366-6999.150083.
6
Comparison of intrathecal bupivacaine and levobupivacaine combined with opioids for Caesarean section.鞘内注射布比卡因和左旋布比卡因联合阿片类药物用于剖宫产的比较。
Curr Med Res Opin. 2007 Dec;23(12):3047-54. doi: 10.1185/030079907X242764.
7
Effect of preemptive intravenous oxycodone on low-dose bupivacaine spinal anesthesia with intrathecal sufentanil.超前静脉注射羟考酮对鞘内注射舒芬太尼的低剂量布比卡因腰麻的影响。
Saudi Med J. 2015 Apr;36(4):437-41. doi: 10.15537/smj.2015.4.10706.
8
Respiratory arrest following intrathecal injection of sufentanil and bupivacaine in a parturient.一名产妇鞘内注射舒芬太尼和布比卡因后发生呼吸骤停。
Can J Anaesth. 1998 Sep;45(9):880-3. doi: 10.1007/BF03012223.
9
Effects of intrathecal and i.v. small-dose sufentanil on the median effective dose of intrathecal bupivacaine for Caesarean section.鞘内及静脉注射小剂量舒芬太尼对剖宫产术鞘内布比卡因半数有效剂量的影响。
Br J Anaesth. 2007 Jun;98(6):792-6. doi: 10.1093/bja/aem101. Epub 2007 May 3.
10
Safety and effectiveness of coadministration of intrathecal sufentanil and morphine in hyperbaric bupivacaine-based spinal anesthesia for cesarean section.鞘内舒芬太尼与吗啡联合用于腰麻-硬膜外联合阻滞下剖宫产术的安全性和有效性。 (注:原英文标题中“hyperbaric bupivacaine-based spinal anesthesia”表述有误,推测正确表述可能是“combined spinal-epidural anesthesia”,即腰麻-硬膜外联合阻滞,以上译文按此推测进行了修正翻译。若实际不是此情况,请根据正确信息调整。)
J Opioid Manag. 2009 Jul-Aug;5(4):197-202. doi: 10.5055/jom.2009.0021.

引用本文的文献

1
Super-refractory status epilepticus, rhabdomyolysis, central hyperthermia and cardiomyopathy attributable to spinal anesthesia: a case report and review of literature.超难治性癫痫持续状态、横纹肌溶解症、中枢性高热和脊髓麻醉相关性心肌病:病例报告及文献复习。
BMC Anesthesiol. 2024 Apr 6;24(1):132. doi: 10.1186/s12871-024-02485-x.

本文引用的文献

1
Severe neurological complications after central neuraxial blockades in Sweden 1990-1999.1990 - 1999年瑞典中枢神经轴索阻滞术后的严重神经并发症
Anesthesiology. 2004 Oct;101(4):950-9. doi: 10.1097/00000542-200410000-00021.
2
Vasodilation increases the threshold for bupivacaine-induced convulsions in rats.血管舒张会提高大鼠对布比卡因诱发惊厥的阈值。
Anesth Analg. 2004 Mar;98(3):677-82, table of contents. doi: 10.1213/01.ane.0000101984.50597.e9.
3
Seizure after levobupivacaine for interscalene brachial plexus block.左旋布比卡因用于肌间沟臂丛神经阻滞术后癫痫发作。
Anesth Analg. 2003 Apr;96(4):1188-1190. doi: 10.1213/01.ANE.0000053235.07186.39.
4
Central nervous system and cardiac effects from long-acting amide local anesthetic toxicity in the intact animal model.完整动物模型中长效酰胺类局部麻醉药毒性对中枢神经系统和心脏的影响。
Reg Anesth Pain Med. 2003 Jan-Feb;28(1):3-11. doi: 10.1053/rapm.2003.50014.
5
Ropivacaine-induced seizure after extradural anaesthesia.
Br J Anaesth. 1998 Jun;80(6):843-4. doi: 10.1093/bja/80.6.843.
6
Adverse effects and drug interactions associated with local and regional anaesthesia.与局部和区域麻醉相关的不良反应及药物相互作用。
Drug Saf. 1998 Apr;18(4):221-50. doi: 10.2165/00002018-199818040-00001.