静脉溶栓后早期恢复与脂蛋白相关磷脂酶 A2 水平呈负相关。
Negative correlation between early recovery and lipoprotein-associated phospholipase A2 levels after intravenous thrombolysis.
机构信息
Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050000, China.
Department of Neurology, North China University of Science and Technology Affiliated Hospital, North China University of Science and Technology, Tangshan, Hebei Province 063000, China.
出版信息
J Int Med Res. 2022 Apr;50(4):3000605221093303. doi: 10.1177/03000605221093303.
OBJECTIVE
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is considered a biomarker for systemic inflammation and the risk of myocardial infarction and stroke. However, little is known about the effect of acute vascular events on marker levels. The purpose of this study was to assess the potential association of early recovery with Lp-PLA2 levels in patients with acute ischemic stroke (AIS) after intravenous thrombolysis (IVT).
METHODS
Forty-three consecutive AIS patients who had their first stroke and were hospitalized within 5 hours of the onset of stroke were enrolled. All patients were treated with IVT using alteplase or urokinase. Plasma Lp-PLA2 levels were measured within 24 hours after IVT. Variables that showed a significant association with Lp-PLA2 in univariate analysis were included in the multivariate ordered logistic regression model.
RESULTS
Early recovery was associated with Lp-PLA2 levels after IVT, and Lp-PLA2 levels tended to decrease with increased probability of early recovery. This study is the first to report a negative correlation between early recovery and Lp-PLA2 levels after IVT.
CONCLUSION
Early recovery after IVT was negatively correlated with Lp-PLA2 A2 levels.
目的
脂蛋白相关磷脂酶 A2（Lp-PLA2）被认为是全身炎症和心肌梗死及中风风险的生物标志物。然而，关于急性血管事件对标志物水平的影响知之甚少。本研究旨在评估急性缺血性脑卒中（AIS）患者静脉溶栓（IVT）后早期恢复与 Lp-PLA2 水平的潜在相关性。
方法
连续纳入 43 例发病 5 小时内首次发生 AIS 并住院的患者。所有患者均采用阿替普酶或尿激酶进行 IVT 治疗。在 IVT 后 24 小时内测量血浆 Lp-PLA2 水平。单因素分析中与 Lp-PLA2 呈显著相关的变量被纳入多变量有序逻辑回归模型。
结果
IVT 后早期恢复与 Lp-PLA2 水平相关，且 Lp-PLA2 水平随早期恢复概率的增加而降低。本研究首次报道了 IVT 后早期恢复与 Lp-PLA2 水平之间的负相关关系。
结论
IVT 后早期恢复与 Lp-PLA2 A2 水平呈负相关。
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