ABEx Bio-Research Center, East Azampur, Dhaka, 1230, Bangladesh.
Department of Pathology, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, 3100, Bangladesh.
Mol Biol Rep. 2022 Oct;49(10):9749-9758. doi: 10.1007/s11033-022-07460-8. Epub 2022 Apr 20.
Chronic kidney disease (CKD) is a worldwide public health concern. Nutritional interventions become a primary concern in managing various diseases, including CKD. Ketogenic diets (KD) are a popular diet and an increasingly used diet for weight loss.
With the increasing cases of CKD, KD has been proposed as a treatment by many scientists. Several studies have shown that KD can slow down the progression rate of renal abnormalities. Also, this diet is regarded as a safe route for managing CKD. CKD is generally associated with increased inflammation, oxidative stress, fibrosis, autophagy dysfunction, and mitochondrial dysfunction, while all of these can be attenuated by KD. The protective effect of KD is mainly mediated through inhibition of ROS, NF-κB, and p62 signaling.
It is suggested that KD could be considered a new strategy for managing and treating CKD more carefully. This review explores the potential of KD on CKD and the mechanism involved in KD-mediated kidney protection.
慢性肾脏病（CKD）是一个全球性的公共卫生关注点。营养干预措施成为管理各种疾病（包括 CKD）的首要关注点。生酮饮食（KD）是一种流行的饮食方式，也是越来越多用于减肥的饮食方式。
随着 CKD 病例的增加，KD 已被许多科学家提出作为一种治疗方法。多项研究表明，KD 可以减缓肾脏异常的进展速度。此外，这种饮食被认为是管理 CKD 的一种安全途径。CKD 通常与炎症增加、氧化应激、纤维化、自噬功能障碍和线粒体功能障碍有关，而 KD 可以减轻所有这些问题。KD 的保护作用主要通过抑制 ROS、NF-κB 和 p62 信号来介导。
建议更仔细地考虑 KD 作为管理和治疗 CKD 的一种新策略。本综述探讨了 KD 在 CKD 中的潜在作用以及 KD 介导的肾脏保护中涉及的机制。
