Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Breast Cancer Res Treat. 2022 Jun;193(3):579-587. doi: 10.1007/s10549-022-06594-4. Epub 2022 Apr 20.
Retrospective analysis of nightly fasting among women with breast cancer suggests that fasting < 13 h may be associated with a higher risk of breast cancer recurrence. We sought to evaluate prolonged overnight fasting (POF), an accessible nonpharmacological intervention, in a prospective feasibility study.
We designed a single-arm, pilot study to evaluate the feasibility of fasting for 13 h overnight for 12 weeks among women with a history of early-stage breast cancer survivors. Baseline and end of study assessments included measurements of body mass index (BMI), blood biomarkers, quality of life (QOL), mood, fatigue, and physical activity. Patient-reported outcome questionnaires were also administered at 6 weeks. Feasibility was defined as ≥ 60% of participants documenting fasting for 13 h on at least 70% of nights during the study period.
Forty women with a history of breast cancer were enrolled with a median age of 60 (range 35-76) and median time since diagnosis of 4.5 years (range 0.8-20.7). At baseline, BMI was ≥ 25 in 37.5%. Ninety-five percent of participants fasted ≥ 13 h for at least 70% of study days (95% CI 83-99%). There was a statistically significant improvement in anxiety (p = 0.0007) at 6 weeks and BMI (p = 0.0072), anxiety (p = 0.0141), depression (p = 0.0048), and fatigue (p = 0.0105) at 12 weeks. There was no significant change in overall QOL, physical activity levels, or blood biomarkers at 12 weeks.
POF is feasible among patients with a history of breast cancer and may potentially improve BMI, mood, and fatigue without detrimental effects on overall QOL.
对乳腺癌女性夜间禁食的回顾性分析表明，禁食时间<13 小时可能与乳腺癌复发风险增加有关。我们旨在通过一项前瞻性可行性研究来评估长时间夜间禁食（POF），这是一种易于实施的非药物干预措施。
我们设计了一项单臂、初步研究，以评估在有早期乳腺癌幸存者病史的女性中，13 小时夜间禁食 12 周的可行性。基线和研究结束时的评估包括体重指数（BMI）、血液生物标志物、生活质量（QOL）、情绪、疲劳和体力活动的测量。患者报告的结果问卷也在 6 周时进行了评估。可行性定义为至少有 60%的参与者在研究期间至少有 70%的夜间记录了 13 小时的禁食时间。
共有 40 名乳腺癌病史的女性入组，中位年龄为 60 岁（范围 35-76 岁），中位诊断后时间为 4.5 年（范围 0.8-20.7 年）。基线时，37.5%的参与者 BMI≥25。95%的参与者至少有 70%的研究天数禁食≥13 小时（95%CI 83-99%）。在 6 周时，焦虑（p=0.0007）和 BMI（p=0.0072）、焦虑（p=0.0141）、抑郁（p=0.0048）和疲劳（p=0.0105）显著改善。在 12 周时，总体 QOL、体力活动水平或血液生物标志物没有显著变化。
POF 在有乳腺癌病史的患者中是可行的，可能潜在地改善 BMI、情绪和疲劳，而不会对总体 QOL 产生不利影响。
