Kleckner Amber S, Clingan Carin L, Youngblood Shari M, Kleckner Ian R, Quick Lauren, Elrod Rebecca D, Zhu Shijun, Manoogian Emily N C, Panda Satchidananda, Badros Ashraf Z, Emadi Ashkan
University of Maryland School of Nursing.
The Salk Institute for Biological Sciences.
Res Sq. 2024 Dec 25:rs.3.rs-5530166. doi: 10.21203/rs.3.rs-5530166/v1.
Time-restricted eating (TRE) helps regulate rest-activity rhythms, blood glucose, and other diurnally regulated energetics processes, which may have implications for persistent fatigue. In a randomized controlled trial, we tested the effects of TRE vs. control on fatigue in cancer survivorship.
Adult cancer survivors were recruited who were 2 months to 2 years post-treatment and reported moderate to severe fatigue. Participants were randomized 1:1, TRE:control and all received individualized nutrition counseling. The TRE group self-selected a 10-hour eating window for 12 weeks. At baseline, week 6, and week 12, participants were asked to log eating instances, complete the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire (FACIT-F, higher score=less fatigue), and wear an actigraph and continuous glucose monitor.
Thirty participants completed baseline assessments and were randomized (77% female, 53% Black/African American, 43% White, 7% Hispanic; 54.1±14.7 years old; 87% with blood cancer); 25 completed 12-week assessments. TRE led to a meaningful reduction in fatigue at week 12 controlling for baseline levels (change in FACIT-F fatigue subscale=0.0±5.4 for control, 4.1±5.7 for TRE, =0.11, effect size [ES]=0.70; clinically meaningful threshold=3.0 points). Glucose parameters (e.g., average interstitial glucose, average fasting glucose) tended to be lower and rest-activity rhythms tended to indicate more regularity for those in the TRE vs. control group at weeks 6 and 12, though differences were not statistically significant (>0.19).
A 12-week, nutritionist-led TRE program led to less fatigue than control. Continued study of TRE patterns are warranted to optimize this eating pattern and address persistent cancer-related fatigue.
限时进食（TRE）有助于调节休息-活动节律、血糖及其他昼夜调节的能量代谢过程，这可能对持续性疲劳有影响。在一项随机对照试验中，我们测试了限时进食与对照饮食对癌症幸存者疲劳的影响。
招募治疗后2个月至2年且报告有中度至重度疲劳的成年癌症幸存者。参与者按1:1随机分组，即限时进食组：对照组，两组均接受个性化营养咨询。限时进食组自行选择10小时的进食窗口，为期12周。在基线、第6周和第12周时，要求参与者记录进食情况，完成慢性病治疗功能评估-疲劳问卷（FACIT-F，得分越高表示疲劳越少），并佩戴活动记录仪和持续血糖监测仪。
30名参与者完成了基线评估并被随机分组（77%为女性，53%为黑人/非裔美国人，43%为白人，7%为西班牙裔；年龄54.1±14.7岁；87%为血癌患者）；25名完成了12周评估。在控制基线水平的情况下，限时进食在第12周时使疲劳有显著减轻（FACIT-F疲劳子量表变化：对照组为0.0±5.4，限时进食组为4.1±5.7，P=0.11，效应量[ES]=0.70；临床意义阈值为3.0分）。在第6周和第12周时，限时进食组的血糖参数（如平均组织间液葡萄糖、平均空腹血糖）往往较低，休息-活动节律往往更规律，尽管差异无统计学意义（P>0.19）。
由营养师指导的为期12周的限时进食计划比对照组导致的疲劳更少。有必要继续研究限时进食模式，以优化这种饮食模式并解决持续性癌症相关疲劳问题。
