Zhu Peide, Wang Siyang, Zhang Yuqi, Li Yifan, Liu Yinping, Li Wenjing, Wang Yuying, Yan Xiang, Luo Dixian
Department of Laboratory Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen 518000, China.
College of New Energy and Materials, China University of Petroleum-Beijing, Beijing 102249, China.
ACS Appl Bio Mater. 2022 May 16;5(5):2031-2045. doi: 10.1021/acsabm.1c01215. Epub 2022 Apr 20.
Despite the rapid development of science and technology, the effective treatment of cancer still threatens human life and health. However, the success of cancer treatment is closely related to early diagnosis, identification, and effective treatment. In recent years, with the strengthening of the development and research of nanomaterials for cancer diagnosis and treatment, researchers have found that carbon dots (CDs) have the advantages of wide absorption, excellent biocompatibility, diverse imaging characteristics, and photostability and are widely used in various fields, such as sensing, imaging, and drug/gene transportation. Recently, researchers also discovered that CDs could be used as an effective photosensitizer to generate active oxygen or convert light energy into heat under the stimulation of the external lasers, making them have the effects of photothermal and photodynamic therapy for cancer. In this review, we first outline the single-modal and multimodal imaging analysis of CDs in cancer cells. After introducing diversified imaging functions, we focused on the design and the latest research progress of CDs in phototherapy and introduced in detail the strategies of CDs in phototherapy treatment and the challenges faced by clinical applications. We hope that this overview can provide important insights for researchers and accelerate the pace of research on CDs in imaging-guided phototherapy treatment.
尽管科学技术飞速发展，但癌症的有效治疗仍然威胁着人类的生命和健康。然而，癌症治疗的成功与早期诊断、识别及有效治疗密切相关。近年来，随着用于癌症诊断和治疗的纳米材料研发力度的加强，研究人员发现碳点（CDs）具有吸收范围广、生物相容性优异、成像特性多样以及光稳定性好等优点，并被广泛应用于传感、成像和药物/基因输送等各个领域。最近，研究人员还发现，碳点在外部激光的刺激下可作为一种有效的光敏剂产生活性氧或将光能转化为热能，使其具有对癌症进行光热和光动力治疗的效果。在本综述中，我们首先概述了碳点在癌细胞中的单模态和多模态成像分析。在介绍了多样化的成像功能之后，我们重点关注了碳点在光疗方面的设计及最新研究进展，并详细介绍了碳点在光疗治疗中的策略以及临床应用所面临的挑战。我们希望这一综述能为研究人员提供重要的见解，并加快碳点在成像引导光疗治疗方面的研究步伐。
