Larsen S A, Farshy C E, Pender B J, Adams M R, Pettit D E, Hambie E A
Sex Transm Dis. 1986 Oct-Dec;13(4):221-7. doi: 10.1097/00007435-198610000-00003.
In 1984 the reporting system for the fluorescent treponemal antibody-absorption (FTA-Abs) test was changed by the Centers for Disease Control (CDC; Atlanta, GA) to eliminate the borderline report. Factors influencing the reliability of the FTA-Abs test results, i.e., sensitivity, specificity, prevalence of syphilis, prescreening of sera with nontreponemal tests, and reproducibility, were considered before the change in the reporting system was recommended and are reported here. The borderline report, when associated with syphilis, was most frequently also associated with the diagnosis of early primary, dark-field-positive, nontreponemal test-nonreactive syphilis. Whereas elimination of the borderline report decreased the sensitivity of the FTA-Abs test as a confirmatory test from 100% to 99.5%, the specificity increased from 82.5% to 88.7%. The 1+ staining intensity had an association of approximately 5% with the diagnosis of syphilis. The changes in the reporting system were designed to assist the clinician in interpreting the results of the FTA-Abs test in those cases that present diagnostic dilemmas.
1984年，美国疾病控制中心（位于佐治亚州亚特兰大）对荧光密螺旋体抗体吸收试验（FTA-Abs）的报告系统进行了更改，以消除“临界”报告。在建议更改报告系统之前，对影响FTA-Abs试验结果可靠性的因素，即敏感性、特异性、梅毒患病率、用非密螺旋体试验对血清进行预筛查以及可重复性进行了考量，并在此报告。当“临界”报告与梅毒相关时，最常与早期一期、暗视野阳性、非密螺旋体试验阴性的梅毒诊断相关。虽然消除“临界”报告使FTA-Abs试验作为确证试验的敏感性从100%降至99.5%，但特异性从82.5%提高到了88.7%。1+染色强度与梅毒诊断的关联约为5%。报告系统的更改旨在帮助临床医生在出现诊断难题的病例中解释FTA-Abs试验的结果。
