Hasselgren P O
Surg Gynecol Obstet. 1987 Feb;164(2):187-96.
Various modalities have been proposed to protect the liver from injury during the ischemic period or after reperfusion. Most of the drugs were administered before the onset of ischemia, but a beneficial effect of post-treatment was reported for MP, dopamine and ATP-MgCl2. Previous studies were mainly performed upon experimental animals, but hypothermia and steroids were used to protect the liver from ischemic injury in patients as well. However, no controlled clinical trials exist demonstrating the efficacy of any type of prevention or treatment in ischemia of the human liver.
已经提出了多种方法来保护肝脏在缺血期或再灌注后免受损伤。大多数药物在缺血发作前给药，但据报道，甲泼尼龙、多巴胺和三磷酸腺苷-氯化镁进行治疗后具有有益效果。先前的研究主要在实验动物身上进行，但低温和类固醇也被用于保护人类患者的肝脏免受缺血性损伤。然而，尚无对照临床试验证明任何类型的预防或治疗方法对人类肝脏缺血有效。
