Fabian W
Chirurgische Klinik des St.-Katharinen-Krankenhauses Frankfurt/M.
Zentralbl Chir. 1990;115(17):1119-31.
In a pilot-study (n = 66) and subsequent controlled experiment (n = 32) the ischemic tolerance of dog liver is examined by means of various clinical and laboratory parameters. During normothermia and without venous decompression the time of ischemic tolerance amounts to 60 minutes. Hypothermia and systemic administration of Aprotinin (Trasylol) and Methylprednisolone (Urbason) do not prolong the tolerance time of ischemia. This time is significantly extended by pre-operative administration of a thiourea-derivate (Propycil). Basing on this decisive improvement of the ischemic tolerance of dog liver, new advances in increasing the ischemic tolerance of human liver are offered.
在一项初步研究（n = 66）及随后的对照实验（n = 32）中，通过各种临床和实验室参数对犬肝的缺血耐受性进行了检查。在常温且无静脉减压的情况下，缺血耐受时间为60分钟。低温以及全身给予抑肽酶（Trasylol）和甲泼尼龙（Urbason）并不会延长缺血耐受时间。术前给予硫脲衍生物（丙基硫氧嘧啶）可显著延长该时间。基于犬肝缺血耐受性的这一决定性改善，为提高人肝缺血耐受性提供了新进展。
