Minina Svetlana V, Shklovskiy-Kordi Nikita E
Institute of Information Transmission Problems, Moscow, Russia.
National Center for Hematology, Moscow, Russia.
Biosystems. 2022 Jul;217:104684. doi: 10.1016/j.biosystems.2022.104684. Epub 2022 Apr 17.
In 1972, Efim Liberman, a Soviet biophysicist, pioneered a brand-new approach to studying the operation of the brain, the live cell and the human mind by publishing a paper titled "Cell as a molecular computer" (1972). In this paper, Liberman posited that a consecutive/parallel stochastic molecular computer (MCC) controls a living cell. An MCC operates with molecule-words (DNA, RNA, proteins) according to the program recorded in DNA and RNA. Computational operations are implemented by molecular operators acting as enzymes. An MCC is present in each live cell. A neuron cell MCC can be involved in solving tasks for the entire organism. Neuron MCC investigation was started with studying an impact of an intracellular injection of cyclic AMP on electric activity of a neuron. Cyclic nucleotides were considered as input words for an MCC, which are generated inside a neuron as a result of synaptic activity. This led Efim Liberman to the idea that, in order to solve complex physical problems, which are encountered by a neuron and require rapid solutions, the molecular computer adjusts the operation of the quantum molecular regulator, which uses the "computational environment" of the cytoskeleton and quantum properties of the elementary hypersound quasiparticles for completing mathematical operations for the minimum price of action. Efim Liberman suggested that the human self-consciousness is a quantum computer of even a higher level and designated it as an extreme quantum regulator. In order to describe such systems, he suggested to join biology, physics and mathematics into a unified science, and formulated its four fundamental principles. Results of Efim Liberman's theoretical and experimental studies on the topic of biological computation are summarized in this review.
1972年,苏联生物物理学家叶菲姆·利伯曼发表了一篇题为《细胞作为分子计算机》(1972年)的论文,开创了一种研究大脑、活细胞和人类思维运作的全新方法。在这篇论文中,利伯曼提出,一台连续/并行随机分子计算机(MCC)控制着一个活细胞。MCC根据记录在DNA和RNA中的程序,利用分子语言(DNA、RNA、蛋白质)进行操作。计算操作由充当酶的分子算子来实现。每个活细胞中都存在一台MCC。神经元细胞的MCC可以参与为整个生物体解决任务。对神经元MCC的研究始于研究细胞内注射环磷酸腺苷对神经元电活动的影响。环核苷酸被视为MCC的输入语言,它们是由于突触活动在神经元内部产生的。这使叶菲姆·利伯曼产生了这样的想法:为了解决神经元遇到的需要快速解决的复杂物理问题,分子计算机调整量子分子调节器的运行,该调节器利用细胞骨架的“计算环境”和基本超音准粒子的量子特性,以最小的作用代价完成数学运算。叶菲姆·利伯曼认为,人类的自我意识是一个更高层次的量子计算机,并将其指定为极端量子调节器。为了描述这样的系统,他建议将生物学、物理学和数学结合成一门统一的科学,并阐述了其四条基本原理。这篇综述总结了叶菲姆·利伯曼关于生物计算主题的理论和实验研究结果。