在受控接触环境烟草烟雾（ETS）后的尿液致突变性。

Urinary mutagenicity after controlled exposure to environmental tobacco smoke (ETS).

作者信息

Scherer G, Westphal K, Biber A, Hoepfner I, Adlkofer F

出版信息

Toxicol Lett. 1987 Jan;35(1):135-40. doi: 10.1016/0378-4274(87)90098-1.

Abstract

20 non-smokers on a defined diet low in polycyclic aromatic hydrocarbons (PAH) were exposed to environmental tobacco smoke (ETS) in an unventilated room for 8 h. The urinary mutagenicity in the 24-h urine samples as tested with the Salmonella (TA98) microsome assay did not significantly increase after exposure to either 10 ppm CO or 20-25 ppm CO. We conclude that exposure of non-smokers to ETS does not lead to an increase in their urinary mutagenicity, provided the exposure conditions are within a realistic range.

摘要

20名食用低多环芳烃（PAH）特定饮食的非吸烟者在不通风的房间里暴露于环境烟草烟雾（ETS）中8小时。用沙门氏菌（TA98）微粒体试验检测24小时尿液样本中的尿致突变性，在暴露于10 ppm一氧化碳或20 - 25 ppm一氧化碳后，尿致突变性没有显著增加。我们得出结论，只要暴露条件在现实范围内，非吸烟者暴露于环境烟草烟雾不会导致其尿致突变性增加。