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追求全能性：培养皿中的真正全能干细胞。

Pursuing totipotency: authentic totipotent stem cells in culture.

机构信息

Department of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.

Department of Medicine, Columbia Center for Human Development, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.

出版信息

Trends Genet. 2022 Jul;38(7):632-636. doi: 10.1016/j.tig.2022.03.012. Epub 2022 Apr 18.

DOI:10.1016/j.tig.2022.03.012
PMID:35443932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9197991/
Abstract

Totipotent stem cells are transiently occurring in vivo cells that can form all cell types of the embryo including placenta, with their in vitro counterparts being actively pursued. Subsequently, totipotent-like cells are established with variable robustness and biological relevance. Here, we summarize current progress on capturing these cells in culture.

摘要

全能干细胞是体内短暂出现的细胞，可以形成包括胎盘在内的胚胎所有细胞类型，其体外对应物也在积极研究中。随后，建立了具有不同稳健性和生物学相关性的类全能干细胞。在这里，我们总结了目前在培养中捕获这些细胞的进展。

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[1]
Pursuing totipotency: authentic totipotent stem cells in culture.

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[2]
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[3]
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[4]
Comparative Analyses of Single-Cell Transcriptomic Profiles between In Vitro Totipotent Blastomere-like Cells and In Vivo Early Mouse Embryonic Cells.

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[5]
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[6]
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[7]
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[8]
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[9]
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引用本文的文献

[1]
Ints7 deficiency activates DNA damage response to elicit resurgence of endogenous retrovirus MERVL and anastasis of embryonic stem cells.

Nucleic Acids Res. 2025-8-11

[2]
Epigenome dynamics in early mammalian embryogenesis.

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[3]
Totipotency or plenipotency: rethinking stem cell bipotentiality.

Curr Opin Genet Dev. 2025-6

[4]
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[5]
Zscan4 mediates ubiquitination and degradation of the corepressor complex to promote chromatin accessibility in 2C-like cells.

Proc Natl Acad Sci U S A. 2024-12-24

[6]
Transposable element activity captures human pluripotent cell states.

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[7]
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[8]
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[9]
Deterministic nuclear reprogramming of mammalian nuclei to a totipotency-like state by Amphibian meiotic oocytes for stem cell therapy in humans.

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[10]
Hyperosmotic stress induces 2-cell-like cells through ROS and ATR signaling.

EMBO Rep. 2023-9-6

本文引用的文献

[1]
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells.

Cell Stem Cell. 2022-3-3

[2]
Human blastoids model blastocyst development and implantation.

Nature. 2022-1

[3]
Engineered models of the human embryo.

Nat Biotechnol. 2021-8

[4]
Mouse totipotent stem cells captured and maintained through spliceosomal repression.

Cell. 2021-5-27

[5]
Evaluating totipotency using criteria of increasing stringency.

Nat Cell Biol. 2021-1

[6]
From pluripotency to totipotency: an experimentalist's guide to cellular potency.

Development. 2020-8-26

[7]
The molecular and cellular features of 2-cell-like cells: a reference guide.

Development. 2020-8-26

[8]
A cell in hand is worth two in the embryo: recent advances in 2-cell like cell reprogramming.

Curr Opin Genet Dev. 2020-10

[9]
DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State.

Cell Stem Cell. 2020-2-6

[10]
Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures.

Cell. 2019-10-17

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