Department of Medicine and Surgery, Pathology, University of Milano-Bicocca, Monza, Italy
Department of Medicine and Surgery, Pathology, University of Milano-Bicocca, Monza, Italy.
J Clin Pathol. 2022 Sep;75(9):588-592. doi: 10.1136/jclinpath-2022-208248. Epub 2022 Apr 20.
Among the different ancillary immunohistochemical tools that pathologists may employ in thyroid nodules, the so-called Hector Battifora's 'MEsothelioma' 1 (HBME-1) staining is one of the most fascinating, since its real identity is currently unknown. In the present review, the different clinical applications of HBME-1 are analysed, with main emphasis on its role in thyroid pathology with overview on less impactful fields, such as haematopathology or mesothelial lesions. Different acceptable or good diagnostic performances were recorded for HBME-1 in thyroid pathology, being used in routine practice as one of the best tools to screen thyroid malignancy both in terms of sensitivity and specificity. From a speculative point of view, after many attempts to hunt the cryptic target antigen of this antibody, its identity still remains elusive. In this setting, the application of high-throughput technologies (mainly in situ proteomics) may be the exact route to improve the knowledge about the pathophysiology of HBME-1 and to finally unveil its true identity.
在病理学家可能用于甲状腺结节的不同辅助免疫组化工具中，所谓的 Hector Battifora 的“间皮瘤”1（HBME-1）染色是最引人注目的工具之一，因为其真实身份目前尚不清楚。在本综述中，分析了 HBME-1 的不同临床应用，主要重点是其在甲状腺病理学中的作用，并概述了对血液病理学或间皮病变等影响较小的领域的作用。HBME-1 在甲状腺病理学中记录了不同可接受或良好的诊断性能，被常规用于筛选甲状腺恶性肿瘤，其在敏感性和特异性方面都是最好的工具之一。从推测的角度来看，在多次尝试寻找该抗体的隐匿靶抗原后，其身份仍然难以捉摸。在这种情况下，高通量技术（主要是原位蛋白质组学）的应用可能是提高对 HBME-1 病理生理学认识并最终揭示其真实身份的确切途径。
