Department of Family Medicine, National Taiwan University Hospital.
Department of Environmental and Occupational Medicine, National Taiwan University Hospital.
J Atheroscler Thromb. 2023 Jan 1;30(1):87-99. doi: 10.5551/jat.63254. Epub 2022 Apr 20.
This study aimed to determine whether sleep disturbance, defined as the wakeup frequency at night, is associated with atherogenic dyslipidemia and to explore possible sex differences.
A total of 1,368 adults aged 19-70 years were included in the study of lifestyles and atherogenic dyslipidemia at the National Taiwan University Hospital in the period of 2008-2012. They completed a questionnaire regarding lifestyle information and sleep quality, including sleep hour duration, use of sleeping pills, and wakeup frequency during nighttime sleep. The measured lipid profiles included total cholesterol, triglycerides, low- and high-density lipoprotein cholesterol (LDL-C and HDL-C, respectively), non-HDL-C, and small dense LDL-C (sdLDL-C). Multivariate logistic regression was performed to determine habitual interrupted sleep and the odds ratio of atherogenic dyslipidemia following adjustment for conventional risk factors and for sex-based subgroup analysis.
A wakeup frequency ≥ 3 times per night was independently associated with an increased risk [odds ratio (95% confidence interval)] of dyslipidemia was 1.96 (1.17-3.28), and non-HDL-C ≥ 160 mg/dL was 1.78 (1.09-2.89). A higher wakeup frequency was associated with increased atherogenic dyslipidemia in women than in men. The multivariate adjusted relative risks for non-HDL ≥ 160 mg/dL and cholesterol ≥ 200 mg/dL were 3.05 (1.27-7.34) and 4.01(1.29-12.45) for female individuals with insomnia and those with a wakeup frequency ≥ 2 times per night, respectively.
A higher wakeup frequency was associated with atherogenic dyslipidemia in Taiwanese adults, particularly in women. This study also provided another evidence of increasing cardiovascular diseases in subjects with habitual interrupted sleep.
本研究旨在确定夜间醒来频率（定义为睡眠障碍）是否与致动脉粥样硬化性血脂异常有关，并探讨可能存在的性别差异。
2008 年至 2012 年，共纳入 1368 名年龄在 19-70 岁的成年人，参与国立台湾大学医院的生活方式与致动脉粥样硬化性血脂异常研究。他们完成了一份关于生活方式信息和睡眠质量的问卷，包括睡眠时间、使用安眠药和夜间睡眠时的醒来频率。测量的血脂谱包括总胆固醇、甘油三酯、低和高密度脂蛋白胆固醇（分别为 LDL-C 和 HDL-C）、非-HDL-C 和小而密 LDL-C（sdLDL-C）。采用多变量 logistic 回归分析来确定习惯性间断睡眠与致动脉粥样硬化性血脂异常的比值比（调整常规危险因素和基于性别的亚组分析后）。
夜间醒来频率≥3 次与血脂异常的风险增加独立相关（比值比[95%置信区间]）为 1.96（1.17-3.28），非-HDL-C≥160mg/dL 为 1.78（1.09-2.89）。较高的醒来频率与女性而非男性的致动脉粥样硬化性血脂异常相关。女性失眠患者和夜间醒来频率≥2 次的患者，非-HDL-C≥160mg/dL 和胆固醇≥200mg/dL 的多变量调整相对风险分别为 3.05（1.27-7.34）和 4.01（1.29-12.45）。
在台湾成年人中，较高的醒来频率与致动脉粥样硬化性血脂异常有关，尤其是女性。本研究还为习惯性间断睡眠的受试者中心血管疾病风险增加提供了另一个证据。
