Ruggiero Angelo, Megna Matteo, Villani Alessia, Comune Rosita, Fabbrocini Gabriella, di Vico Francesca
Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, 80131, Italy.
Section of Radiology and Radiotherapy, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, 80138, Italy.
Clin Cosmet Investig Dermatol. 2022 Apr 14;15:661-673. doi: 10.2147/CCID.S267573. eCollection 2022.
Bullous pemphigoid (BP) is the most frequent autoimmune bullous disease mainly affecting elderlies. Diagnosis usually results from clinical features, histological examination, and the quantification of circulating typical autoantibodies, due to its higher incidence in elderly patients, bullous pemphigoid treatment and management still represents a challenge due to the higher frequency of several comorbidities in this group of patients, which may also be linked to a reduced tolerance to BP treatments. Hence, an early diagnosis and a prompt correct treatment are mandatory to reach better clinical outcomes and improve as much as possible BP outcomes. Herein, we carried out a comprehensive literature review about the known clinical presentations, diagnosis, assessment and monitoring procedures used in daily clinical practice in patients with BP, to better define strategies to improve as much as possible BP clinical outcomes.
大疱性类天疱疮（BP）是最常见的自身免疫性大疱性疾病，主要影响老年人。诊断通常基于临床特征、组织学检查以及循环中典型自身抗体的定量检测。由于老年患者中其发病率较高，大疱性类天疱疮的治疗和管理仍然是一项挑战，因为该组患者中多种合并症的发生率较高，这也可能与对BP治疗的耐受性降低有关。因此，早期诊断和及时正确的治疗对于获得更好的临床结局以及尽可能改善BP的预后是必不可少的。在此，我们对BP患者日常临床实践中使用的已知临床表现、诊断、评估和监测程序进行了全面的文献综述，以更好地确定尽可能改善BP临床结局的策略。
