Aviles Gonzalez Cesar Ivan, Angermeyer Matthias, Deiana Laura, Loi Caterina, Murgia Elisabetta, Holzinger Anita, Cossu Giulia, Massa Elena, Romano Ferdinando, Scartozzi Mario, Carta Mauro Giovanni
Universidad Popular del Cesar, Valledupar, Colombia.
Center for Public Mental Health, Gösinhg am Wagram, Austria.
Clin Pract Epidemiol Ment Health. 2021 Dec 31;17(1):315-323. doi: 10.2174/1745017902117010315. eCollection 2021.
Suffering from Solid Cancer (SC) may adversely impact the Health-related Quality of Life (H-QoL). The aims of this study are to measure the H-QoL in a sample of people suffering from SC and to clarify the role of the co-occurrence of depressive episodes. Results were compared with a healthy control group and with groups of other disorders.
In 151 patients with SC (mean±sd age 63.1±11.5; female 54.3%), H-QoL was assessed by SF-12, depressive episodes were identified by PHQ-9. The attributable burden of SC in impairing H-QoL was calculated as the difference between SF-12 score of a community sex and age ¼ matched healthy control group and that of the study sample. The attributable burden of SC was compared with other chronic diseases using specific diagnostic groups drawn from case-control studies that used the same database for selecting control samples.
H-QoL in people with SC was significantly worse than in the healthy control group (p<0.0001). The attributable burden in worsening the H-QoL due to SC was similar to those of severe chronic diseases, but lower than Multiple Sclerosis (p<0.0001) or Fibromyalgia (p<0.00001). Having a depressive episode was a strong determinant of decreasing H-QoL, regardless of the severity of cancer.
The findings confirm a strong impact of SC but showed that H-QoL in SC was higher than in chronic diseases with better "quoad vitam" outcome. Since depression was a strong determinant, its prevention, early detection and therapy are the main objectives that must be reached in cancer patients.
患有实体癌（SC）可能会对健康相关生活质量（H-QoL）产生不利影响。本研究的目的是测量实体癌患者样本中的健康相关生活质量，并阐明抑郁发作共病的作用。将结果与健康对照组以及其他疾病组进行比较。
对151例实体癌患者（平均年龄±标准差为63.1±11.5岁；女性占54.3%），采用SF-12评估健康相关生活质量，采用PHQ-9识别抑郁发作。实体癌损害健康相关生活质量的归因负担计算为社区中按性别和年龄四分之一匹配的健康对照组与研究样本的SF-12得分之差。使用从病例对照研究中提取的特定诊断组，将实体癌的归因负担与其他慢性疾病进行比较，这些病例对照研究使用相同的数据库选择对照样本。
实体癌患者的健康相关生活质量显著低于健康对照组（p<0.0001）。实体癌导致健康相关生活质量恶化的归因负担与严重慢性疾病相似，但低于多发性硬化症（p<0.0001）或纤维肌痛（p<0.00001）。无论癌症严重程度如何，有抑郁发作都是健康相关生活质量下降的一个重要决定因素。
研究结果证实了实体癌有很强的影响，但表明实体癌患者的健康相关生活质量高于预后较好的慢性疾病患者。由于抑郁症是一个重要决定因素，其预防、早期发现和治疗是癌症患者必须实现的主要目标。
