University of Cagliari, Cagliari, Italy
University of Cagliari, Cagliari, Italy.
Int J Soc Psychiatry. 2015 Nov;61(7):693-9. doi: 10.1177/0020764015573848. Epub 2015 Mar 12.
INTRODUCTION/OBJECTIVE: The aim was to measure the lifetime prevalence of panic disorder (PD) in an Italian community sample, and to estimate the burden attributable to PD in compromising the quality of life (QoL) of people diagnosed with it.
Community survey was conducted on a sample of 4,999 randomly selected adult subjects. Instruments used were semi-structured clinical interview Advanced Neuropsychiatric Tools and Assessment Schedule (ANTAS), administered by clinicians and allowing diagnosis according to Diagnostic and Statistical Manual of Mental Disorder (4th ed.; DSM-IV); Short Form Health Survey (SF-12).
The lifetime prevalence of PD was 3.6% (4.4% in females, 2.5% in males; p = .002). People with PD had a lower SF-12 score than the standardized community sample (35.5 ± 6.5 vs. 38.4 ± 5.9; p < .0001) with a mean difference (attributable burden) of 2.9 ± 0.7, that is, lower than PD with agoraphobia (AP; 4.2 ± 2.4). Wilson Disease (WD), Multiple Sclerosis, Major Depressive Disorder and Eating Disorders (ED) show a higher attributable burden in impaired QoL than PD, while the attributable burden of PD with AP is not lower than in ED and WD.
The burden attributable to the impairment of QoL following a lifetime diagnosis of PD was found to be not so great compared to the impairment caused by Major Depressive Disorder (MDD) or neurological conditions. The comorbidity of PD with AP worsens QoL significantly.
简介/目的：本研究旨在测量意大利社区样本中惊恐障碍（PD）的终身患病率，并估计 PD 对患者生活质量（QoL）的损害负担。
对 4999 名随机选择的成年受试者进行社区调查。使用的工具是由临床医生进行的半结构式临床访谈高级神经精神工具和评估计划（ANTAS），根据《精神障碍诊断与统计手册》（第四版；DSM-IV）进行诊断；健康调查简表（SF-12）。
PD 的终身患病率为 3.6%（女性为 4.4%，男性为 2.5%；p=0.002）。PD 患者的 SF-12 评分低于标准化社区样本（35.5±6.5 与 38.4±5.9；p<0.0001），平均差异（归因负担）为 2.9±0.7，即低于伴有广场恐怖症（AP）的 PD（4.2±2.4）。Wilson 病（WD）、多发性硬化症、重性抑郁障碍和饮食障碍（ED）在 QoL 受损方面的归因负担均高于 PD，而伴有 AP 的 PD 的归因负担并不低于 ED 和 WD。
与重性抑郁障碍（MDD）或神经疾病引起的损害相比，PD 导致的 QoL 损害归因负担被认为不那么严重。PD 伴 AP 的共病会显著降低 QoL。
