童年逆境、产前抑郁与孕期全程的母体炎症
Childhood adversity, prenatal depression, and maternal inflammation across pregnancy.
作者信息
Bublitz Margaret H, Freeburg Taylor, Sharp Meghan, Salameh Myriam, Bourjeily Ghada
机构信息
Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, RI, USA.
出版信息
Obstet Med. 2022 Mar;15(1):25-30. doi: 10.1177/1753495X211011910. Epub 2021 May 11.
BACKGROUND
To examine whether change in neutrophil-lymphocyte ratio, a marker of systemic inflammation, differs by childhood adversity and prenatal depression.
METHODS
Prenatal complete blood count data were used to calculate neutrophil-lymphocyte ratio in first and third trimesters. The Adverse Childhood Experiences scale measured childhood adversity, and the Patient Health Questionnaire-9 measured depression. This is a secondary analysis of a study of predictors of risk for sleep-disordered breathing.
RESULTS
Participants were 98 pregnant women, mean age 30 years ( = 5), mean body mass index of 35 kg/m ( = 7), 61% identified as white, and 28% identified as Hispanic. Women who reported childhood sexual abuse history displayed greater increase in neutrophil-lymphocyte ratio over pregnancy relative to women without childhood sexual abuse. Change in neutrophil-lymphocyte ratio across pregnancy did not differ by prenatal depression.
CONCLUSION
Experiences of sexual abuse in childhood may impact markers of systemic inflammation in pregnancy.
背景
探讨全身炎症标志物中性粒细胞与淋巴细胞比值的变化是否因童年逆境和产前抑郁而有所不同。
方法
利用产前全血细胞计数数据计算孕早期和孕晚期的中性粒细胞与淋巴细胞比值。儿童期不良经历量表用于测量童年逆境，患者健康问卷-9用于测量抑郁。这是一项关于睡眠呼吸障碍风险预测因素研究的二次分析。
结果
参与者为98名孕妇，平均年龄30岁（标准差=5），平均体重指数为35kg/m²（标准差=7），61%为白人，28%为西班牙裔。报告有童年性虐待史的女性相对于没有童年性虐待史的女性，在孕期中性粒细胞与淋巴细胞比值的增加幅度更大。孕期中性粒细胞与淋巴细胞比值的变化在产前抑郁方面没有差异。
结论
童年期性虐待经历可能会影响孕期全身炎症的标志物。
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