Department of Child and Adolescent Psychiatry, New York University Langone Medical Center, New York, NY, USA.
Department of Basic Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Curr Psychiatry Rep. 2023 Apr;25(4):149-164. doi: 10.1007/s11920-023-01414-y. Epub 2023 Mar 22.
To synthesize and critically examine recent evidence regarding associations between immune system activity and perinatal depression.
Despite a significant number of studies assessing potential immunological markers of perinatal depression, it does not appear that levels of any individual pro- or anti-inflammatory marker is a useful predictor of perinatal depression. Some recent studies have observed differences in overall immune system functioning and adaptation across this period, taking into account multiple pro- and anti- inflammatory markers. Furthermore, there is evidence for interactions between depression and maternal psychosocial factors. Immune system functioning may be a mechanism through which social determinants of health contribute to risk for perinatal depression. There is substantial evidence implicating dysregulated immune activity in perinatal depression, yet little clarity regarding a consistent immune profile, especially based on analysis of circulating peripheral cytokines.
综合并批判性地考察近期有关免疫系统活动与围产期抑郁之间关联的证据。
尽管有大量研究评估了围产期抑郁的潜在免疫标志物，但似乎没有任何单一的促炎或抗炎标志物的水平可作为围产期抑郁的有用预测指标。一些最近的研究观察到在这一时期，考虑到多种促炎和抗炎标志物，整个免疫系统的功能和适应性存在差异。此外，还有证据表明抑郁与产妇心理社会因素之间存在相互作用。免疫系统功能可能是健康的社会决定因素导致围产期抑郁风险的一种机制。有大量证据表明，调节性免疫活动与围产期抑郁有关，但基于对循环外周细胞因子的分析，对于一致的免疫特征，特别是基于对循环外周细胞因子的分析，仍缺乏明确性。
