Farquhar Hannah E, Lamprecht Annabelle
Department of Obstetric Medicine, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Department of Endocrinology and Diabetes, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Obstet Med. 2022 Mar;15(1):68-70. doi: 10.1177/1753495X20980251. Epub 2021 Jan 4.
Thromboangiitis obliterans, also known as Buerger's disease, is rarely reported in young women in pregnancy. It is an occlusive vascular disorder, characterised by episodic non-atherosclerotic thrombosis of small- and medium-sized blood vessels. Thromboangiitis obliterans predominantly occurs in males aged less than 50 years and is almost exclusively diagnosed in smokers. The small number of published cases have frequently reported worsening of thrombotic symptoms, due to the hypercoagulable state of pregnancy, and potential pregnancy complications of intra-uterine growth restriction and pre-term labour. This report provides a summary of the literature and outlines the case of a pregnant 23-year-old female with thromboangiitis obliterans, who was managed with low-dose enoxaparin and aspirin. Her thrombotic symptoms were stable during pregnancy; however, her pregnancy was complicated by placental malperfusion and intra-uterine growth restriction.
血栓闭塞性脉管炎，又称伯格氏病，在孕期年轻女性中鲜有报道。它是一种闭塞性血管疾病，其特征是中小血管出现间歇性非动脉粥样硬化性血栓形成。血栓闭塞性脉管炎主要发生在50岁以下男性，几乎仅在吸烟者中被诊断出来。少数已发表的病例经常报告，由于妊娠的高凝状态，血栓形成症状会加重，以及存在子宫内生长受限和早产等潜在妊娠并发症。本报告总结了相关文献，并概述了一名患有血栓闭塞性脉管炎的23岁孕妇的病例，该孕妇接受了低剂量依诺肝素和阿司匹林治疗。她在孕期的血栓形成症状稳定；然而，她的妊娠因胎盘灌注不良和子宫内生长受限而出现并发症。
