Soltany Amjad, Hraib Munawar, Alkhayer Mawya, Ibraheem Batoul, Alshehabi Zuheir
Department of Plastic and Reconstructive Surgery, Al Mouwasat University Hospital, Faculty of Medicine, Damascus University, Damascus, Syria.
Faculty of Medicine, Cancer Research Centre, Tishreen University, Latakia, Syria.
Ann Med Surg (Lond). 2022 Apr 5;77:103587. doi: 10.1016/j.amsu.2022.103587. eCollection 2022 May.
to determine the clinical presentations and histopathological findings of idiopathic granulomatous mastitis, and to evaluate clinical outcomes after management.
between 2007 and 2021, the files and histopathology reports of 17 patients with idiopathic granulomatous mastitis at Tishreen University Hospital, Latakia, Syria were reviewed. The data were analyzed and a scan through relevant literature was carried out to review related cases.
the age of patients ranged from 23 years to 57 years, and the mean age was 37.2 ± 9.57 years. All patients were female. The most common clinical presentation was breast lumps and the most common mammographic finding was ill-defined masses, which mimics breast carcinoma. Multinucleated giant cells, polymorphonuclear leukocytes, lipogranuloma-like changes and lobulocentric abscesses were the most common histopathological findings. Treatment options include: drainage of abscess along with antibiotics, steroid administration, and surgical excision. Antibiotic treatment was associated with a higher rate of complications, while use of steroids showed complete remission of the disease.
idiopathic granulomatous mastitis is a spectrum of entities that should be differentiated from breast carcinoma and other mastitis conditions, the infectious or the non-infectious ones. The clinical and radiological features resemble those of breast carcinoma and infectious mastitis. The histopathological study is considered as the most crucial element in the multidisciplinary approach to diagnose idiopathic granulomatous mastitis (IGM) and determine the optimal management to be administered.
确定特发性肉芽肿性乳腺炎的临床表现和组织病理学发现，并评估治疗后的临床结果。
回顾2007年至2021年叙利亚拉塔基亚市提什林大学医院17例特发性肉芽肿性乳腺炎患者的病历和组织病理学报告。对数据进行分析，并查阅相关文献以回顾相关病例。
患者年龄在23岁至57岁之间，平均年龄为37.2±9.57岁。所有患者均为女性。最常见的临床表现是乳房肿块，最常见的乳腺X线表现是边界不清的肿块，类似乳腺癌。多核巨细胞、多形核白细胞、脂肉芽肿样改变和小叶中心性脓肿是最常见的组织病理学发现。治疗选择包括：脓肿引流联合抗生素、使用类固醇以及手术切除。抗生素治疗并发症发生率较高，而使用类固醇可使疾病完全缓解。
特发性肉芽肿性乳腺炎是一系列疾病实体，应与乳腺癌和其他乳腺炎情况（感染性或非感染性）相鉴别。其临床和放射学特征类似于乳腺癌和感染性乳腺炎。组织病理学研究被认为是多学科方法诊断特发性肉芽肿性乳腺炎（IGM）并确定最佳治疗方案时的关键要素。
