Lilley Cullen, Grech Joseph, Martinbianco Emily, Chen Xiuxu
Department of Pathology, Loyola University Chicago Stritch School of Medicine, Maywood, USA.
Department of Pathology, Loyola University Medical Center, Maywood, USA.
Cureus. 2022 Mar 14;14(3):e23140. doi: 10.7759/cureus.23140. eCollection 2022 Mar.
Human intestinal spirochetosis (HIS) refers to the colonization of spirochetal bacteria in the human intestinal tract. HIS caused by spp. has been recognized for decades, but their pathological and clinical significance is largely unclear. The coincidence of dysplasia in adenoma or adenocarcinoma and HIS is very rare, and whether spirochetes can colonize on dysplastic epithelium remains controversial. Here, we report a case that showed abrupt abolition of mucosal surface fringe formation on a tubular adenoma (TA) and increased cytoplasmic MUC1 expression in the dysplastic epithelial cells compared with adjacent nondysplastic colonocytes. The findings support the hypothesis that the epithelial colonization of spirochetes is significantly reduced by dysplasia likely due to loss of microvilli, and an increase of epithelial MUC1 expression might contribute to reduced spirochetal colonization in colonic mucosa.
人类肠道螺旋体病（HIS）是指螺旋体细菌在人体肠道内的定植。由特定菌种引起的HIS已被认识数十年，但其病理和临床意义在很大程度上尚不清楚。腺瘤或腺癌发育异常与HIS的巧合非常罕见，螺旋体是否能在发育异常的上皮细胞上定植仍存在争议。在此，我们报告一例病例，该病例显示管状腺瘤（TA）黏膜表面边缘形成突然消失，与相邻的非发育异常结肠细胞相比，发育异常上皮细胞中的细胞质MUC1表达增加。这些发现支持了这样一种假说，即发育异常可能由于微绒毛丧失而显著减少螺旋体的上皮定植，而上皮MUC1表达的增加可能导致结肠黏膜中螺旋体定植减少。
