Brooke C J, Riley T V, Hampson D J
School of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA 6150, Australia.
Epidemiol Infect. 2006 Jun;134(3):627-34. doi: 10.1017/S0950268805005170.
This study examined the prevalence of the intestinal spirochaetes Brachyspira aalborgi and Brachyspira pilosicoli in different Western Australian (WA) populations. Faecal samples included 287 from rural patients with gastrointestinal symptoms, comprising 142 from non-Aboriginal and 145 from Aboriginal people; 227 from recent healthy migrants to WA from developing countries; and 90 from healthy non-Aboriginal individuals living in Perth, WA. DNA was extracted from faeces, and subjected to PCR assays for both species. B. pilosicoli-positive individuals were confined to the rural Aboriginal (14.5%) and migrant (15.0%) groups. B. aalborgi was detected at a lower but similar prevalence in all four groups: rural non-Aboriginals, 5.6%; rural Aboriginals, 6.9%; migrants, 7.9%; controls, 5.6%. In migrants and Aborigines, the presence of B. pilosicoli and B. aalborgi was associated (P<0.001), suggesting that colonization by B. pilosicoli may be facilitated by colonization with B. aalborgi. Amongst the Aboriginal patients, logistic regression identified both spirochaete species as being associated with chronic diarrhoea, failure to thrive and being underweight. Both species may have pathogenic potential, but B. aalborgi appears more host-adapted than the opportunistic B. pilosicoli.
本研究调查了肠道螺旋体——奥尔堡短螺旋体和柔毛短螺旋体在西澳大利亚不同人群中的流行情况。粪便样本包括287份来自有胃肠道症状的农村患者，其中142份来自非原住民，145份来自原住民；227份来自近期从发展中国家移民至西澳大利亚的健康人群；以及90份来自居住在西澳大利亚珀斯的健康非原住民个体。从粪便中提取DNA，并对这两种螺旋体进行聚合酶链反应检测。柔毛短螺旋体阳性个体仅限于农村原住民组（14.5%）和移民组（15.0%）。在所有四组中均检测到奥尔堡短螺旋体，其流行率较低但相似：农村非原住民组为5.6%；农村原住民组为6.9%；移民组为7.9%；对照组为5.6%。在移民和原住民中，柔毛短螺旋体和奥尔堡短螺旋体的存在具有相关性（P<0.001），这表明奥尔堡短螺旋体的定植可能有助于柔毛短螺旋体的定植。在原住民患者中，逻辑回归分析表明这两种螺旋体均与慢性腹泻、发育不良和体重不足有关。这两种螺旋体可能都具有致病潜力，但与机会性的柔毛短螺旋体相比，奥尔堡短螺旋体似乎更适应宿主。
