B CUBE - Center for Molecular Bioengineering, Technische Universität Dresden, 01307 Dresden, Germany.
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Nano Lett. 2022 May 11;22(9):3659-3667. doi: 10.1021/acs.nanolett.2c00255. Epub 2022 Apr 21.
Gold nanowires have great potential use as interconnects in electronic, photonic, and optoelectronic devices. To date, there are various fabrication strategies for gold nanowires, each one associated with particular drawbacks as they utilize high temperatures, toxic chemicals, or expensive compounds to produce nanowires of suboptimal quality. Inspired by nanowire fabrication strategies that used higher-order biopolymer structures as molds for electroless deposition of gold, we here report a strategy for the growth of gold nanowires from seed nanoparticles within the lumen of microtubules. Luminal targeting of seed particles occurs through covalently linked Fab fragments of an antibody recognizing the acetylated lysine 40 on the luminal side of α-tubulin. Gold nanowires grown by electroless deposition within the microtubule lumen exhibit a homogeneous morphology and high aspect ratios with a mean diameter of 20 nm. Our approach is fast, simple, and inexpensive and does not require toxic chemicals or other harsh conditions.
金纳米线在电子、光子和光电设备的互连中具有巨大的应用潜力。迄今为止，已经有多种制造金纳米线的方法，但每种方法都存在特定的缺点，因为它们利用高温、有毒化学物质或昂贵的化合物来生产质量较差的纳米线。受利用高级生物聚合物结构作为无电沉积金的模具的纳米线制造策略的启发，我们在此报告了一种在微管腔中从种子纳米颗粒生长金纳米线的策略。通过与识别微管腔内α-微管蛋白上乙酰化赖氨酸 40 的抗体的 Fab 片段共价连接，实现种子颗粒的管腔靶向。在微管腔中通过无电沉积生长的金纳米线具有均匀的形态和高纵横比，平均直径为 20nm。我们的方法快速、简单且廉价，不需要有毒化学物质或其他苛刻的条件。
