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抗精神病药物与被诊断患有破坏性行为障碍的寄养青少年入住精神科住院治疗设施。

Antipsychotic medications and admission to psychiatric residential treatment facilities among youth in foster care diagnosed with disruptive behavior disorders.

机构信息

School of Social Work.

School of Pharmacy.

出版信息

Am J Orthopsychiatry. 2022;92(4):474-482. doi: 10.1037/ort0000624. Epub 2022 Apr 21.

DOI:10.1037/ort0000624
PMID:35446103
Abstract

Many youth in foster care are diagnosed with disruptive behavior disorder (DBD), a diagnosis indicative of aggression and behavior problems. These youth, who are at high risk for being placed in psychiatric residential treatment facilities (PRTF), are commonly prescribed antipsychotic (AP) medications off-label. However, treating children in the community is an important goal, and although AP medications can have severe side effects, these prescriptions may help to achieve this goal. In this study, we used Medicaid data to determine whether AP medications reduce the risk of admission to PRTF among two groups of children with DBD: those with DBD only and those who were diagnosed with DBD in addition to at least one of two conditions indicated for AP prescribing (psychosis and bipolar disorder.) Event history models show that AP medications are associated with a high rate of admission, which are likely due to the higher mental and behavioral health needs of youth who are prescribed. However, youth diagnosed with both DBD and indications who are prescribed an AP medication have one-tenth the rate of admission of similar youth who are not prescribed. For youth with DBD only, the findings are inconclusive. Given these mixed results, practitioners should follow clinical guidelines; ensuring youth are treated with psychosocial interventions and other psychotropic medications prior to AP prescribing. Agencies should attempt to address systemic factors such as shortages of foster homes, increased availability of therapeutic foster care, and implementation of in-home prevention services. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

摘要

许多寄养中的年轻人被诊断出患有破坏性行为障碍 (DBD),这一诊断表明他们存在攻击性和行为问题。这些年轻人被安置在精神病住院治疗机构 (PRTF) 的风险很高,他们通常被开处非典型抗精神病药物 (AP)。然而,在社区中治疗儿童是一个重要目标,尽管 AP 药物可能有严重的副作用,但这些处方可能有助于实现这一目标。在这项研究中,我们使用医疗补助数据来确定 AP 药物是否能降低两组患有 DBD 的儿童被 PRTF 收治的风险:仅患有 DBD 的儿童和除了至少一种 AP 药物适应证(精神病和双相情感障碍)之外还被诊断患有 DBD 的儿童。事件史模型表明,AP 药物与高收治率相关,这可能是由于开处这些药物的年轻人的精神和行为健康需求更高。然而,同时被诊断患有 DBD 和适应证并被开处 AP 药物的年轻人的收治率只有未被开处 AP 药物的相似年轻人的十分之一。对于仅患有 DBD 的年轻人,结果尚无定论。鉴于这些混合结果,从业者应遵循临床指南;确保在开处 AP 药物之前,对年轻人进行心理社会干预和其他精神药物治疗。各机构应努力解决寄养家庭短缺、治疗性寄养增加和家庭预防服务实施等系统性问题。(PsycInfo 数据库记录 (c) 2022 APA,保留所有权利)。

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