Department of Anesthesiology, Columbia University Irving Medical Center, New York, New York.
Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York.
JAMA Netw Open. 2022 Apr 1;5(4):e228520. doi: 10.1001/jamanetworkopen.2022.8520.
Characterizing and addressing racial and ethnic disparities in peripartum pain assessment and treatment is a national priority.
To evaluate the association of race and ethnicity with the provision and timing of an epidural blood patch (EBP) for management of postdural puncture headache in obstetric patients.
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used New York State hospital discharge records from January 1, 1998, to December 31, 2016, from mothers 15 to 49 years of age with a postdural puncture headache after neuraxial analgesia or anesthesia for childbirth. Statistical analysis was performed from February 2020 to February 2022.
Patients' race and ethnicity (reported as provided by each participating hospital; the method of determining race and ethnicity [ie, self-reported or not] cannot be determined from the data) were categorized into non-Hispanic White (reference group), non-Hispanic Black, Hispanic, and other race and ethnicity (including Asian and Pacific Islander, American Indian, Alaskan Native, and other).
The primary outcome was the rate of EBP use. The secondary outcome was the interval (days) between hospital admission and provision of EBP. Odds ratios (ORs) and 95% CIs of EBP use associated with race and ethnicity were estimated using mixed-effect logistic regression models, adjusting for patient and hospital characteristics.
During the study period, 8921 patients (mean [SD] age, 30 [6] years; 1028 [11.5%] Black; 1301 [14.6%] Hispanic; 4960 [55.6%] White; and 1359 [15.2%] other race and ethnicity) with postdural puncture headache were identified among 1.9 million deliveries with a neuraxial procedure. Of these 8921 patients, 4196 (47.0%; 95% CI, 46.0%-48.1%) were managed with an EBP. A total of 2650 White patients (53.4%; 95% CI, 52.0%-54.8%) used an EBP; this rate was significantly higher than that among Hispanic patients (41.7% [543]; 95% CI, 39.9%-44.5%), Black patients (35.7% [367]; 95% CI, 32.8%-38.7%), or patients of other race and ethnicity (35.2% [478]; 95% CI, 32.6%-37.8%). Timing of EBP was at a median of 2 days (IQR, 2-3 days) after hospital admission for White patients compared with a median of 3 days (IQR, 2-4 days) for Hispanic patients, Black patients, and patients of other race and ethnicity (P < .001 for the comparison with White patients). After adjustment for patient and hospital characteristics, the EBP rate was not different between White and Hispanic patients (adjusted OR, 1.11; 95% CI, 0.94-1.30). It was significantly lower for Black patients (adjusted OR, 0.80; 95% CI, 0.67-0.94) and patients of other races and ethnicities (adjusted OR, 0.85; 95% CI, 0.73-0.99).
In this study, significant racial and ethnic disparities in the management of postdural puncture headache with EBP were observed, with both lower rates and delayed timing, which may be associated with long-term adverse effects.
重要性:描述和解决围产期疼痛评估和治疗中的种族和民族差异是国家的优先事项。
目的:评估种族和民族与椎管内血贴(EBP)用于管理产科患者硬脊膜穿刺后头痛的提供和时机之间的关联。
设计、设置和参与者:这项横断面研究使用了纽约州 1998 年 1 月 1 日至 2016 年 12 月 31 日的医院出院记录,来自 15 至 49 岁的产妇,她们在分娩时接受了椎管内镇痛或麻醉后出现硬脊膜穿刺后头痛。统计分析于 2020 年 2 月至 2022 年 2 月进行。
暴露:患者的种族和民族(由每个参与医院提供;无法从数据中确定种族和民族的确定方法[即自我报告或不报告])被分为非西班牙裔白人(参照组)、非西班牙裔黑人、西班牙裔和其他种族和民族(包括亚洲和太平洋岛民、美洲印第安人、阿拉斯加原住民和其他)。
主要结果和措施:主要结果是 EBP 的使用率。次要结果是入院到 EBP 提供之间的间隔(天)。使用混合效应逻辑回归模型估计与种族和民族相关的 EBP 使用的比值比(OR)和 95%置信区间,调整了患者和医院特征。
结果:在研究期间,在 190 万例接受神经轴程序分娩的患者中,确定了 8921 例硬脊膜穿刺后头痛患者(平均[SD]年龄,30[6]岁;1028[11.5%]黑人;1301[14.6%]西班牙裔;4960[55.6%]白人;1359[15.2%]其他种族和民族)。在这 8921 例患者中,有 4196 例(47.0%;95%CI,46.0%-48.1%)接受了 EBP 治疗。共有 2650 名白人患者(53.4%;95%CI,52.0%-54.8%)使用了 EBP;这一比率明显高于西班牙裔患者(41.7%[543];95%CI,39.9%-44.5%)、黑人患者(35.7%[367];95%CI,32.8%-38.7%)或其他种族和民族患者(35.2%[478];95%CI,32.6%-37.8%)。EBP 的时间中位数为入院后 2 天(IQR,2-3 天),而西班牙裔患者的中位数为 3 天(IQR,2-4 天),黑人患者和其他种族和民族患者的中位数为 3 天(IQR,2-4 天)。(P<.001)与白人患者相比。在调整了患者和医院特征后,白人患者和西班牙裔患者的 EBP 使用率没有差异(调整后的 OR,1.11;95%CI,0.94-1.30)。黑人患者(调整后的 OR,0.80;95%CI,0.67-0.94)和其他种族和民族患者(调整后的 OR,0.85;95%CI,0.73-0.99)的比率明显较低。
结论和相关性:在这项研究中,观察到 EBP 治疗硬脊膜穿刺后头痛的管理存在显著的种族和民族差异,无论是在使用率还是在时间延迟方面,这可能与长期不良后果有关。