Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Andalas, Padang, Indonesia.
Undergraduate Pharmacy Study Programme, Faculty of Pharmacy, Universitas Andalas, Padang, Indonesia.
J Complement Integr Med. 2022 Apr 21;19(3):627-636. doi: 10.1515/jcim-2022-0054. eCollection 2022 Sep 1.
Antioxidants protect people from diabetes and its cardiovascular complication. Purified gambir ( Roxb.) is a potential medicinal plant for treating this condition based on the antioxidant activity of its catechin compound. This study tries to reveal the potential activity of purified gambir as a blood pressure-lowering drug while lowering blood glucose in diabetic hypertensive rats induced by oral NaCl-Prednisone and Alloxan.
Rats were induced by oral NaCl 0.8% and Prednisone 5 mg/kg BW for 14 days to obtain hypertensive condition. Alloxan 125 mg/kg BW was given intra peritoneal injection on the 8th day to obtain diabetic hypertensive condition. The animal was divided into five groups, normal control group treated with vehicle, treatment groups were treated with purified gambir at dose of 2.5; 5 and 10 mg/kg BW respectively, while the positive control group were treated with a combination of captopril-glibenclamide at dose of 2.25 and 0.45 mg/kg BW. All animals were treated orally for 14 days. Fasting blood glucose and cardiovascular parameters (SBP, DBP, MAP, HR, BF and BV) were measured on days 1, 3, 7, and 14. NO level were measured on day 0 and day 14. Data were analyzed using two-way ANOVA followed by Duncan Multiple Range Test.
The purified gambir has blood pressure and blood sugar-lowering activity (p<0.05). The NO levels of the treatment group also increased significantly (p<0.05).
This study indicated that purified gambir could be an alternative medicine to manage blood glucose and blood pressure in the diabetic hypertensive model.
抗氧化剂可预防糖尿病及其心血管并发症。基于其儿茶素化合物的抗氧化活性，纯化荜茇（Roxb.）是一种有潜力的治疗这种疾病的药用植物。本研究试图揭示纯化荜茇作为降压药物的潜在活性，同时降低由口服 NaCl-泼尼松和链脲佐菌素诱导的糖尿病高血压大鼠的血糖。
大鼠通过口服 0.8%NaCl 和 5mg/kg BW 泼尼松诱导 14 天以获得高血压状态。第 8 天腹腔内注射 125mg/kg BW 链脲佐菌素以获得糖尿病高血压状态。动物分为 5 组，正常对照组给予载体，治疗组分别给予纯化荜茇 2.5、5 和 10mg/kg BW 治疗，阳性对照组给予卡托普利-格列本脲联合治疗，剂量分别为 2.25 和 0.45mg/kg BW。所有动物均口服治疗 14 天。于第 1、3、7 和 14 天测量空腹血糖和心血管参数（SBP、DBP、MAP、HR、BF 和 BV）。于第 0 天和第 14 天测量 NO 水平。采用双因素方差分析，然后进行邓肯多重范围检验分析数据。
纯化荜茇具有降血压和降血糖作用（p<0.05）。治疗组的 NO 水平也显著升高（p<0.05）。
本研究表明，纯化荜茇可能是治疗糖尿病高血压模型中血糖和血压的替代药物。
