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2018 年中国重庆一起饮用自制药酒导致的中毒事件

Poisoning Associated with Consumption of a Homemade Medicinal Liquor - Chongqing, China, 2018.

出版信息

MMWR Morb Mortal Wkly Rep. 2022 Apr 22;71(16):569-573. doi: 10.15585/mmwr.mm7116a2.

DOI:10.15585/mmwr.mm7116a2
PMID:35446826
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9042358/
Abstract

On May 3, 2018, Chongqing Center for Disease Control and Prevention (CQCDC) received a report of 15 persons with numbness of the tongue or limbs and vomiting of unknown etiology; all ill persons had attended an adult birthday luncheon in Bishan District, Chongqing municipality, in southwest China. Initial reports indicated that one person had died. Within 2 hours, CQCDC and Western Chinese Field Epidemiology Training Program staff members launched an investigation that included identification of cases, laboratory testing of drinks, and patient interviews to identify the cause of what appeared to be a poisoning. Among the 15 cases, five persons died. The investigation of this apparent mass intoxication implicated a homemade alcoholic beverage produced from a highly toxic flowering plant in the genus Aconitum used in traditional Chinese medicine. Although the risk of aconite toxicity is known, approximately 5,000 cases of aconite poisoning incidents were reported in China, Germany, Japan, and other countries during 1993-2005; most cases of fatal poisoning occurred in China (1). This event highlights the importance of enforcing and complying with existing regulations regarding sale and purchase of Aconitum species (also known as wolfbane), and of dissemination of critical public health messages.

摘要

2018 年 5 月 3 日,重庆市疾病预防控制中心(CQCDC)收到报告称,有 15 人出现舌头发麻或四肢麻木、呕吐等不明原因症状;所有患者均参加了在中国西南部重庆市璧山区举行的成人生日午宴。初步报告显示,有 1 人死亡。CQCDC 和西部中国现场流行病学培训项目的工作人员在接到报告后 2 小时内启动了调查,包括对病例的确认、对饮料的实验室检测以及对患者的访谈,以确定看似中毒的原因。在 15 例病例中,有 5 人死亡。此次疑似群体性中毒事件涉及一种自制的含酒精饮料,该饮料由一种在传统中药中使用的毒性很强的乌头属植物制成。虽然众所周知乌头毒性的风险,但在 1993 年至 2005 年期间,中国、德国、日本和其他国家报告了大约 5000 例乌头中毒事件;大多数致命中毒病例发生在中国(1)。这一事件突显了执行和遵守有关销售和购买乌头属物种(也称为狼毒)的现有法规以及传播关键公共卫生信息的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/741c/9042358/4c98e76e0192/mm7116a2-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/741c/9042358/fc02b7851bf1/mm7116a2-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/741c/9042358/4c98e76e0192/mm7116a2-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/741c/9042358/fc02b7851bf1/mm7116a2-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/741c/9042358/4c98e76e0192/mm7116a2-F2.jpg

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本文引用的文献

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Case reports of aconite poisoning in mainland China from 2004 to 2015: A retrospective analysis.2004年至2015年中国大陆乌头中毒病例报告:一项回顾性分析。
J Forensic Leg Med. 2016 Aug;42:68-73. doi: 10.1016/j.jflm.2016.05.016. Epub 2016 May 25.
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Aconitum alkaloid poisoning related to the culinary uses of aconite roots.与乌头根烹饪用途相关的乌头生物碱中毒。
Toxins (Basel). 2014 Sep 2;6(9):2605-11. doi: 10.3390/toxins6092605.
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Aconitine alters connexin43 phosphorylation status and [Ca2+] oscillation patterns in cultured ventricular myocytes of neonatal rats.乌头碱改变新生大鼠培养心室肌细胞中连接蛋白43的磷酸化状态及[Ca2+]振荡模式。
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Disruption of the intracellular Ca2+ homeostasis in the cardiac excitation-contraction coupling is a crucial mechanism of arrhythmic toxicity in aconitine-induced cardiomyocytes.乌头碱诱导的心肌细胞中,细胞内钙离子稳态在心脏兴奋-收缩偶联过程中的破坏是心律失常毒性的关键机制。
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