Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea.
Department of Life Sciences, Korea University, Seoul 02841, Republic of Korea.
J Radiat Res. 2022 May 18;63(3):342-353. doi: 10.1093/jrr/rrac016.
Glioblastoma is a deadly cancer tumor in the brain and has a survival rate of about 15 months. Despite the high mortality rate, temozolomide has proven to increase the survival rate of patients when combined with radiotherapy. However, its effects may be limited because some patients develop therapeutic resistance. Curcumin has proven to be a cancer treatment due to its broad anticancer spectrum, high efficiency and low toxic level. Additionally, curcumin significantly enhanced radiation efficacy under high and low Linear Energy Transfer (LET) radiation conditions in vitro. In combination with radiation, curcumin increased the cell population in the sub-G1 phase and the reactive oxygen species (ROS) level, ultimately increasing GBM cellular apoptosis. The radiosensitizing effects of curcumin are much higher in neutron (high LET)-irradiated cell lines than in γ (low LET)-irradiated cell lines. Curcumin plus neutron combination significantly inhibited cell invasion compared with that of single treatment or curcumin combined γ-ray treatment. Curcumin enhances the radiosensitivity of Glioblastoma (GBM), suggesting it may have clinical utility in combination cancer treatment with neutron high-LET radiation.
胶质母细胞瘤是一种致命的脑部癌症肿瘤，其生存率约为 15 个月。尽管死亡率很高，但替莫唑胺已被证明与放射治疗联合使用时可以提高患者的生存率。然而，其效果可能有限，因为一些患者会产生治疗抵抗。姜黄素由于其广泛的抗癌谱、高效和低毒性水平，已被证明是一种癌症治疗方法。此外，姜黄素在体外高和低线性能量转移（LET）辐射条件下显著增强了辐射效果。与辐射联合使用时，姜黄素增加了亚 G1 期细胞群体和活性氧（ROS）水平，最终增加了 GBM 细胞凋亡。姜黄素在中子（高 LET）辐照细胞系中的放射增敏作用比γ（低 LET）辐照细胞系高得多。与单一治疗或姜黄素联合γ射线治疗相比，姜黄素加中子联合显著抑制了细胞侵袭。姜黄素增强了胶质母细胞瘤（GBM）的放射敏感性，表明它可能在与中子高 LET 辐射联合癌症治疗方面具有临床应用价值。
