Hong Su Jung, Garcia Coralia V, Shin Gye Hwa, Kim Jun Tae
Department of Food and Nutrition, BioNanocomposite Research Center, Kyung Hee University, Seoul 02447, Republic of Korea.
Independent Researcher, Mexico.
Int J Biol Macromol. 2022 Jun 1;209(Pt A):895-903. doi: 10.1016/j.ijbiomac.2022.04.066. Epub 2022 Apr 18.
W/O/W double emulsion-based iron-solid lipid nanoparticles (Fe-SLNs) and water-soluble chitosan-coated Fe-SLNs (WSC-Fe-SLNs) were developed to increase the bioaccessibility and stability of iron. Fe-SLNs exhibited a small diameter (158.17 ± 0.72 nm) and adequate zeta potential (-34.31 ± 0.41 mV) to maintain stable dispersion. The coating with WSC resulted in an increase in particle diameter (up to 226.13 ± 1.97 nm) and change of zeta potential to positive value (+47.83 ± 1.24 mV) because of the amine groups of chitosan. The lipid peroxidation of the Fe-SLNs and WSC-Fe-SLNs was substantially lower than that of pure iron. Both Fe-SLNs and WSC-Fe-SLNs were also able to protect the encapsulated iron in simulated gastric fluid, while effectively releasing almost 80% of the iron in simulated intestinal fluid. The Fe-SLNs and WSC-Fe-SLNs showed a great potential as functional materials to apply to various food industries through enhancement of physical stability and bioaccessibility of the encapsulated iron.
开发了基于水包油包水双乳液的铁固体脂质纳米颗粒（Fe-SLNs）和水溶性壳聚糖包被的Fe-SLNs（WSC-Fe-SLNs），以提高铁的生物可及性和稳定性。Fe-SLNs呈现出较小的直径（158.17±0.72nm）和足够的ζ电位（-34.31±0.41mV）以维持稳定的分散体。用WSC包被导致粒径增加（高达226.13±1.97nm），并且由于壳聚糖的胺基，ζ电位变为正值（+47.83±1.24mV）。Fe-SLNs和WSC-Fe-SLNs的脂质过氧化作用显著低于纯铁。Fe-SLNs和WSC-Fe-SLNs在模拟胃液中也能够保护包封的铁，同时在模拟肠液中有效释放近80%的铁。通过提高包封铁的物理稳定性和生物可及性，Fe-SLNs和WSC-Fe-SLNs作为功能材料应用于各种食品工业显示出巨大潜力。
