生物医用微球在创伤愈合中的应用。
Application of Biomedical Microspheres in Wound Healing.
机构信息
State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning 530021, China.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
出版信息
Int J Mol Sci. 2023 Apr 15;24(8):7319. doi: 10.3390/ijms24087319.
Tissue injury, one of the most common traumatic injuries in daily life, easily leads to secondary wound infections. To promote wound healing and reduce scarring, various kinds of wound dressings, such as gauze, bandages, sponges, patches, and microspheres, have been developed for wound healing. Among them, microsphere-based tissue dressings have attracted increasing attention due to the advantage of easy to fabricate, excellent physicochemical performance and superior drug release ability. In this review, we first introduced the common methods for microspheres preparation, such as emulsification-solvent method, electrospray method, microfluidic technology as well as phase separation methods. Next, we summarized the common biomaterials for the fabrication of the microspheres including natural polymers and synthetic polymers. Then, we presented the application of the various microspheres from different processing methods in wound healing and other applications. Finally, we analyzed the limitations and discussed the future development direction of microspheres in the future.
组织损伤是日常生活中最常见的创伤之一，容易导致二次伤口感染。为了促进伤口愈合和减少疤痕形成，已经开发出了各种伤口敷料，如纱布、绷带、海绵、贴片和微球，用于伤口愈合。其中，基于微球的组织敷料由于易于制备、优异的物理化学性能和出色的药物释放能力而引起了越来越多的关注。在本文中，我们首先介绍了微球制备的常见方法，如乳化-溶剂法、电喷法、微流控技术以及相分离法。接下来，我们总结了用于制备微球的常见生物材料，包括天然聚合物和合成聚合物。然后，我们介绍了不同加工方法的各种微球在伤口愈合和其他应用中的应用。最后，我们分析了微球的局限性，并讨论了未来微球的发展方向。
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