Adelipour Maryam, Saleth Leena Regi, Ghavami Saeid, Alagarsamy Keshav Narayan, Dhingra Sanjiv, Allameh Abdolamir
Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Canada.
Biochim Biophys Acta Mol Basis Dis. 2022 Aug 1;1868(8):166412. doi: 10.1016/j.bbadis.2022.166412. Epub 2022 Apr 18.
Autophagy is a very well-coordinated intracellular process that maintains cellular homeostasis under basal conditions by removing unnecessary or dysfunctional components through orderly degradation and recycling. Under pathological conditions, defects in autophagy have been linked to various human disorders, including neurodegenerative disorders and cancer. The role of autophagy in stem cell proliferation, differentiation, self-renewal, and senescence is well documented. Additionally, cancer stem cells (CSCs) play an important role in tumorigenesis, metastasis and tumor relapse and several studies have suggested the involvement of autophagy in the maintenance and invasiveness of CSCs. Hence, considering the modulation of autophagy in normal and cancer stems cells as a therapeutic approach can lead to the development or improvement of regenerative and anti-cancer therapies. Accordingly, modulation of autophagy can be regarded as a target for stem cell-based therapy of diseases with abnormal levels of autophagy. This article is focused on understanding the role of autophagy in stem cell homeostasis with an emphasis on the therapeutic potential of targeting autophagy for future therapies.
自噬是一个协调良好的细胞内过程，在基础条件下通过有序降解和循环清除不必要或功能失调的成分来维持细胞内稳态。在病理条件下，自噬缺陷与包括神经退行性疾病和癌症在内的各种人类疾病有关。自噬在干细胞增殖、分化、自我更新和衰老中的作用已有充分记录。此外，癌症干细胞（CSCs）在肿瘤发生、转移和肿瘤复发中起重要作用，多项研究表明自噬参与了癌症干细胞的维持和侵袭。因此，将正常和癌症干细胞中的自噬调节作为一种治疗方法可能会导致再生和抗癌疗法的发展或改进。相应地，自噬调节可被视为基于干细胞治疗自噬水平异常疾病的一个靶点。本文重点在于理解自噬在干细胞内稳态中的作用，强调靶向自噬在未来治疗中的治疗潜力。
