School of Education Science, Hunan Normal University, Chang Sha, 410081, China; Cognition and Human Behavior Key Laboratory of Hunan Province, Hunan Normal University, Chang Sha, 410081, China.
School of Education Science, Hunan Normal University, Chang Sha, 410081, China; Cognition and Human Behavior Key Laboratory of Hunan Province, Hunan Normal University, Chang Sha, 410081, China.
Sleep Med. 2022 Jun;94:8-16. doi: 10.1016/j.sleep.2022.03.023. Epub 2022 Apr 1.
Emotion plays an important role in sleep quality, meanwhile, poor sleep quality is usually correlated with high negative emotions (NES). However, less is known about the neural basis for NES and the underlying mechanism for how NES affect individuals' sleep quality in the health brain. The present study combined voxel-based morphometry and resting-state functional connectivity analysis to identify the relationship between brain regions and NES, and then explored how NES-related brain structures are related to sleep quality in a large sample of normal young adults.
The present study used a fMRI procedure. Participants were 339 normal young adults. The NES was represented by the principal components of four measures: the Self-rating Anxiety Scale, Self-rating Depression Scale, Negative Affect Schedule, and Psychosomatic Tension Relaxation Inventory. Sleep quality was measured using the Pittsburgh Sleep Quality Index.
Results showed that higher NES scores were associated with larger regional gray matter volume (rGMV) in the left parahippocampal gyrus, right superior temporal gyrus, and right postcentral gyrus. Further functional connectivity analysis demonstrated that the connectivity between these three brain regions and a specific set of emotion-related regions was also significantly associated with NES scores. Moreover, NES acted as a mediator of the relationship between the rGMV of the left parahippocampal gyrus, right superior temporal gyrus, and right postcentral gyrus and sleep quality. NES also mediated the relationship between the connectivity between the right superior temporal-supplementary motor area and the right superior temporal-right precentral gyrus and sleep quality.
The present study provides the further evidence for neural substrates of NES and reveals a potential mechanism that NES mediates the effect of spontaneous brain activity on sleep quality. Meanwhile, these findings indicate that negative emotions share a common brain structure and function based on sleep quality.
情绪在睡眠质量中起着重要作用，同时，睡眠质量差通常与高负性情绪（NES）有关。然而，对于 NES 的神经基础以及 NES 如何影响健康大脑个体的睡眠质量的潜在机制知之甚少。本研究结合基于体素的形态测量和静息态功能连接分析，确定了脑区与 NES 之间的关系，然后在大量正常年轻成年人中探讨了与 NES 相关的脑结构与睡眠质量之间的关系。
本研究采用 fMRI 程序。参与者为 339 名正常年轻成年人。NES 由四项测量的主成分来表示：自评焦虑量表、自评抑郁量表、负性情绪量表和身心紧张松弛量表。睡眠质量采用匹兹堡睡眠质量指数进行测量。
结果表明，较高的 NES 评分与左侧海马旁回、右侧颞上回和右侧中央后回的区域灰质体积（rGMV）增大有关。进一步的功能连接分析表明，这三个脑区与一组特定的情绪相关脑区之间的连接也与 NES 评分显著相关。此外，NES 作为左侧海马旁回、右侧颞上回和右侧中央后回 rGMV 与睡眠质量之间关系的中介，也作为右侧颞上-辅助运动区与右侧颞上-中央前回之间连接与睡眠质量之间关系的中介。
本研究为 NES 的神经基础提供了进一步的证据，并揭示了 NES 介导自发脑活动对睡眠质量影响的潜在机制。同时，这些发现表明，负面情绪基于睡眠质量共享共同的脑结构和功能。
