Neurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, Pakistan.
Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, Pakistan.
J Food Biochem. 2021 Dec;45(12):e13989. doi: 10.1111/jfbc.13989. Epub 2021 Oct 31.
Peripheral nerve damage is a debilitating condition that can result in partial or complete functional loss as a result of axonal degeneration, as well as lifelong dependence. Many therapies have been imbued with a plethora of positive features while posing little risks. It is worth noting that these biomolecules work by activating several intrinsic pathways that are known to be important in peripheral nerve regeneration. Although the underlying mechanism is used for accurate and speedy functional recovery, none of them are without side effects. As a result, it is believed that effective therapy is currently lacking. The dietary biomolecules-based intervention, among other ways, is appealing, safe, and effective. Upregulation of transcription factors, neurotrophic factors, and growth factors such as NGF, GDNF, BDNF, and CTNF may occur as a result of these substances' dietary intake. Upregulation of the signaling pathways ERK, JNK, p38, and PKA has also been seen, which aids in axonal regeneration. Although several mechanistic approaches to understanding their involvement have been suggested, more work is needed to reveal the amazing properties of these biomolecules. We have discussed in this article that how different dietary biomolecules can help with functional recovery and regeneration after an injury. PRACTICAL APPLICATIONS: Based on the information known to date, we may conclude that treatment techniques for peripheral nerve injury have downsides, such as complications, donor shortages, adverse effects, unaffordability, and a lack of precision in efficacy. These difficulties cast doubt on their efficacy and raise severe concerns about the prescription. In this situation, the need for safe and effective therapeutic techniques is unavoidable, and dietary biomolecules appear to be a safe, cost-efficient, and effective way to promote nerve regeneration following an injury. The information on these biomolecules has been summarized here. Upregulation of transcription factors, neurotrophic factors, and growth factors, such as NGF, GDNF, BDNF, and CTNF, as well as the ERK, JNK, p38, and PKA, signaling pathways, may stimulate axonal regeneration.
周围神经损伤是一种使人虚弱的疾病，会导致轴突退化以及终身依赖，从而导致部分或完全功能丧失。许多疗法具有许多积极的特征，同时风险很小。值得注意的是，这些生物分子通过激活几个内在途径发挥作用，这些途径已知在周围神经再生中很重要。虽然这种潜在的机制用于实现准确和快速的功能恢复，但没有一种方法没有副作用。因此，目前认为有效的治疗方法是缺乏的。基于饮食的生物分子的干预，除其他方式外，是吸引人的、安全的和有效的。这些物质的饮食摄入可能导致转录因子、神经营养因子和生长因子（如 NGF、GDNF、BDNF 和 CTNF）的上调。还观察到 ERK、JNK、p38 和 PKA 信号通路的上调，这有助于轴突再生。尽管已经提出了几种理解其参与作用的机制方法，但仍需要更多的工作来揭示这些生物分子的惊人特性。在本文中，我们讨论了不同的饮食生物分子如何帮助受伤后的功能恢复和再生。实际应用：根据目前已知的信息，我们可以得出结论，外周神经损伤的治疗技术存在一些缺点，如并发症、供体短缺、不良反应、负担能力和疗效缺乏精确性。这些困难对其疗效提出了质疑，并对处方提出了严重的担忧。在这种情况下，需要安全有效的治疗技术是不可避免的，而饮食生物分子似乎是一种安全、具有成本效益且有效的促进损伤后神经再生的方法。这里总结了这些生物分子的信息。转录因子、神经营养因子和生长因子（如 NGF、GDNF、BDNF 和 CTNF）的上调，以及 ERK、JNK、p38 和 PKA 信号通路，可能刺激轴突再生。
