深海来源真菌的新型 3-酰基四氢嘧啶衍生物
New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus .
机构信息
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin 541004, China.
出版信息
Mar Drugs. 2022 Apr 6;20(4):255. doi: 10.3390/md20040255.
Seven rare C3-C6 reduced 3-acyl tetramic acid derivatives, lecanicilliumins A-G (-), along with the known analogue cladosporiumin D (), were obtained from the extract of the deep-sea-derived fungus GXIMD00542 within the family Clavipitacae. Their structures were elucidated by extensive spectroscopic data analysis, quantum chemistry calculations and chemical reaction. Compounds , , - exhibited moderate anti-inflammatory activity against NF-κB production using lipopolysaccharide (LPS) induced RAW264.7 cells with EC values range of 18.49-30.19 μM.
七种罕见的 C3-C6 还原 3-酰基四氢酸衍生物，lecanicilliumins A-G（-），以及已知的类似物 cladosporiumin D（），是从深海来源的真菌 GXIMD00542 的提取物中获得的，该真菌属于clavipitacae 科。通过广泛的光谱数据分析、量子化学计算和化学反应，阐明了它们的结构。化合物、、-对脂多糖（LPS）诱导的 RAW264.7 细胞中 NF-κB 产生表现出中等的抗炎活性，EC 值范围为 18.49-30.19 μM。
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