Rasing Naomi L, Janus Sarah I M, Kreutz Gunter, Sveinsdottir Vigdis, Gold Christian, Nater Urs M, Zuidema Sytse U
Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen, 9700 AD Groningen, The Netherlands.
Department of Music, Speech and Music Lab, Carl von Ossietzky University Oldenburg, Ammerländer Heerstraße 114-118, 26129 Oldenburg, Germany.
Brain Sci. 2022 Apr 8;12(4):485. doi: 10.3390/brainsci12040485.
Recently, a large cluster-randomized controlled trial was designed-Music Interventions for Dementia and Depression in ELderly care (MIDDEL)-to assess the effectiveness of music interventions on depression in care home residents with dementia (ClinicalTrials.gov NCT03496675). To understand the pathophysiological mechanisms, we observed the effect of repeated music interventions on stress in this population since chronic stress was associated with depression and an increased risk for dementia. An exploratory study was designed to assess: (1) changes in hair cortisol concentrations as an indicator of longer-term stress; (2) whether baseline stress is a predictor of therapy outcome; (3) pre- and post-treatment effects on salivary α-amylase and cortisol response as an indicator of immediate stress in 180-200 care home residents with dementia and depressive symptoms who partake in the MIDDEL trial. Insights into mediatory effects of stress to explain the effect of music interventions will be gained. Hair cortisol concentrations were assessed at baseline and at 3, 6, and 12 months along with the Perceived Stress Scale. Salivary α-amylase and cortisol concentrations were assessed at 1, 3, and 6 months. Saliva was collected just before a session and 15 and 60 min after a session, along with a stress Visual Analogue Scale.
最近，一项大型整群随机对照试验——老年护理中痴呆与抑郁的音乐干预（MIDDEL）——旨在评估音乐干预对患有痴呆症的养老院居民抑郁症状的有效性（ClinicalTrials.gov标识符：NCT03496675）。为了解其病理生理机制，鉴于慢性应激与抑郁及痴呆风险增加相关，我们观察了重复音乐干预对该人群应激的影响。设计了一项探索性研究来评估：（1）作为长期应激指标的头发皮质醇浓度变化；（2）基线应激是否为治疗结果的预测指标；（3）对180 - 200名参与MIDDEL试验、患有痴呆症和抑郁症状的养老院居民，治疗前后唾液α-淀粉酶和皮质醇反应作为即时应激指标的影响。将深入了解应激的中介作用，以解释音乐干预的效果。在基线以及3个月、6个月和12个月时评估头发皮质醇浓度，并同时使用感知应激量表。在1个月、3个月和6个月时评估唾液α-淀粉酶和皮质醇浓度。在每次疗程前、疗程后15分钟和60分钟收集唾液，并同时使用应激视觉模拟量表。
