Velayutham Nivedhitha, Yutzey Katherine E
The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
J Cardiovasc Dev Dis. 2022 Mar 23;9(4):93. doi: 10.3390/jcdd9040093.
Swine are popular large mammals for cardiac preclinical testing due to their similarities with humans in terms of organ size and physiology. Recent studies indicate an early neonatal regenerative capacity for swine hearts similar to small mammal laboratory models such as rodents, inspiring exciting possibilities for studying cardiac regeneration with the goal of improved clinical translation to humans. However, while swine hearts are anatomically similar to humans, fundamental differences exist in growth mechanisms, nucleation, and the maturation of pig cardiomyocytes, which could present difficulties for the translation of preclinical findings in swine to human therapeutics. In this review, we discuss the maturational dynamics of pig cardiomyocytes and their capacity for proliferative cardiac regeneration during early neonatal development to provide a perspective on swine as a preclinical model for developing cardiac gene- and cell-based regenerative therapeutics.
猪是用于心脏临床前测试的常见大型哺乳动物，因为它们在器官大小和生理方面与人类相似。最近的研究表明，猪心脏在新生儿早期具有再生能力，类似于啮齿动物等小型哺乳动物实验室模型，这为研究心脏再生带来了令人兴奋的可能性，目标是改善向人类的临床转化。然而，虽然猪心脏在解剖学上与人类相似，但在生长机制、成核以及猪心肌细胞的成熟方面存在根本差异，这可能给将猪的临床前研究结果转化为人类治疗方法带来困难。在这篇综述中，我们讨论了猪心肌细胞在新生儿早期发育过程中的成熟动态及其增殖性心脏再生能力，以提供关于猪作为开发基于心脏基因和细胞的再生治疗方法的临床前模型的观点。
